Zfhep Inhibitors
Chemical inhibitors of Zfhep can interfere with its function through various methods that target different aspects of cellular processes. Paclitaxel, for instance, exerts its inhibitory action by stabilizing microtubules, which are critical for cell division. Since Zfhep plays a role in cellular processes that require division, the stabilization of microtubules caused by paclitaxel can lead to an inhibition of Zfhep's function by disrupting the normal cycle of microtubule assembly and disassembly. Similarly, Roscovitine targets cyclin-dependent kinases, key regulators of the cell cycle. By impeding these kinases, Roscovitine can halt the progression of the cell cycle, indirectly inhibiting the processes in which Zfhep is involved. Thapsigargin, which inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase, leads to an increase in cytosolic calcium levels, affecting a myriad of cellular functions including those regulated by Zfhep, resulting in its functional inhibition. Brefeldin A adds another layer of inhibition by disrupting protein trafficking through the inhibition of ADP-ribosylation factor, which is crucial for the formation of vesicles from the Golgi apparatus, potentially preventing proper localization and function of proteins that work in concert with Zfhep.
Continuing with the theme of signal transduction interference, LY294002 and Wortmannin both inhibit phosphoinositide 3-kinases, key components in pathways governing cell growth and survival, thus potentially inhibiting Zfhep functions related to these signals. U0126 and PD98059 are inhibitors that target the MAPK/ERK pathway by blocking MEK, subsequently leading to a blockade of cell proliferation and differentiation signals where Zfhep is implicated. DAPT, by inhibiting gamma-secretase, can obstruct the Notch signaling pathway, which is an essential pathway for Zfhep's role in cell processes. SB431542 specifically targets TGF-beta signaling by inhibiting the TGF-beta type I receptor ALK5, thereby influencing the functional capabilities of Zfhep through this pathway. Rapamycin, an inhibitor of mTOR, can reduce the signaling required for the cellular processes involving Zfhep due to mTOR's role in regulating cell growth and proliferation. Lastly, SP600125 inhibits c-Jun N-terminal kinase, implicated in controlling gene expression for apoptosis and cell proliferation, which can alter stress response signaling pathways and lead to the functional inhibition of Zfhep.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and consequently inhibits their disassembly, which is crucial for mitotic spindle formation during cell division. As Zfhep is involved in developmental processes that require cell division, paclitaxel's action on microtubules can inhibit Zfhep function by disrupting cellular division where Zfhep is active. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a selective inhibitor of cyclin-dependent kinases (CDKs). By inhibiting CDKs, roscovitine prevents the cell cycle progression. Since Zfhep is implicated in cell differentiation and proliferation, inhibiting cell cycle regulators like CDKs can result in functional inhibition of Zfhep. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium levels. Elevated intracellular calcium can disrupt multiple cellular processes, including those regulated by Zfhep, thereby functionally inhibiting its activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts protein trafficking by inhibiting the ADP-ribosylation factor (ARF), which is a key protein in vesicle formation from the Golgi apparatus. This disruption can inhibit Zfhep function by blocking proper localization and trafficking of proteins that interact with or regulate Zfhep. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in signaling pathways controlling cell growth and survival. By inhibiting PI3K, LY294002 can inhibit pathways that are crucial for Zfhep functions related to cellular growth and survival signals. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. Inhibition of MEK by U0126 can lead to functional inhibition of Zfhep by blocking the MAPK/ERK pathway that regulates cell proliferation and differentiation where Zfhep is also involved. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT is a gamma-secretase inhibitor that can inhibit the Notch signaling pathway. Since Zfhep has been implicated in Notch signaling, inhibiting this pathway with DAPT can result in the functional inhibition of Zfhep by preventing Notch-mediated cellular processes. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 selectively inhibits the transforming growth factor-beta (TGF-beta) type I receptor ALK5, which is involved in TGF-beta signaling. Inhibition of this pathway can functionally inhibit Zfhep by blocking TGF-beta signaling processes where Zfhep may play a role. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, and mTOR is a key regulator of cell growth and proliferation. By inhibiting mTOR, rapamycin can inhibit the function of Zfhep by reducing the signaling required for the cellular processes in which Zfhep is involved. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which blocks the MAPK/ERK pathway. By inhibiting this pathway, PD98059 can lead to functional inhibition of Zfhep by preventing the transduction of signals for cell growth and differentiation. | ||||||