ZC3H12C Activators
ZC3H12C activators are compounds that serve to enhance the protein's functional activity by interfacing with specific cellular signaling pathways. Forskolin, by increasing intracellular cAMP levels, activates PKA, leading to the phosphorylation of substrates that interact with ZC3H12C, thereby enhancing its role in RNA metabolism. Sphingosine-1-phosphate, through its action on G-protein-coupled receptors, activates MAPK signaling, which in turn positively influences ZC3H12C's function in inflammatory response regulation. PMA, as a PKC activator, contributes to the enhancement of ZC3H12C's activity by modulating signaling pathways that intersect with the protein's regulatory functions. Furthermore, Staurosporine, though a general kinase inhibitor, can have selective effects that potentially enhance the activity of ZC3H12C by reducing competitive kinase signaling, allowing ZC3H12C to modulate RNA metabolism more effectively.
Genistein's influence on tyrosine kinase pathways results in a signaling environment that is conducive to the enhanced activity of ZC3H12C. Thapsigargin and A23187, by increasing intracellular calcium levels, activate calcium-dependent proteins that may indirectly enhance ZC3H12C's role in mRNA stability and immune response regulation. Additionally, Epigallocatechin gallate (EGCG), through its inhibition of various kinases, modulates signaling pathways to favor ZC3H12C's involvement in post-transcriptional gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly increases intracellular cAMP levels. Elevated cAMP activates PKA (Protein Kinase A), which can phosphorylate regulatory proteins, thereby enhancing the functional activity of ZC3H12C in RNA metabolism and decay. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate interacts with its G-protein-coupled receptors to activate downstream MAPK signaling. This activation has the potential to enhance the functional activity of ZC3H12C by promoting its role in inflammatory response regulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a PKC activator that mimics diacylglycerol. Activation of PKC can lead to the phosphorylation of proteins that are involved in the modulation of RNA-binding proteins, thereby enhancing the functional activity of ZC3H12C in mRNA destabilization. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor. While its effects are wide-ranging, it can selectively enhance the activity of ZC3H12C by reducing competitive kinase signaling, which may otherwise suppress ZC3H12C's function in RNA metabolism. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin raises intracellular calcium levels, which can activate calcium-dependent protein kinases and phosphatases, indirectly enhancing the activity of ZC3H12C in the control of mRNA stability. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can enhance the functional activity of ZC3H12C by reducing competition from tyrosine kinase signaling pathways, allowing ZC3H12C to more effectively regulate inflammatory response genes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor found in green tea with the potential to modulate multiple signaling pathways. This modulation can indirectly enhance the activity of ZC3H12C in post-transcriptional gene regulation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, leading to the activation of calcium-dependent signaling pathways which may enhance the regulatory function of ZC3H12C in immune response. | ||||||