ZAP-70 Activators
ZAP-70 activators are a category of molecules that play a pivotal role in the regulation of immune cell signaling, particularly within T lymphocytes. ZAP-70, or Zeta-chain-associated protein kinase 70, is a cytoplasmic tyrosine kinase that acts as a critical component in the antigen receptor signaling pathway in T cells. This class of activators comprises various small molecules and biochemical compounds that are designed to modulate the activity of ZAP-70. These activators are of great interest in the field of immunology and cell biology as they offer a means to dissect and manipulate the intricate signaling pathways that govern T cell activation and immune responses.
At a molecular level, ZAP-70 activators typically function by either enhancing or inhibiting the kinase activity of ZAP-70. By doing so, they can regulate downstream signaling events that influence T cell activation, proliferation, and cytokine production. Understanding and manipulating ZAP-70 activation is crucial for deciphering the intricacies of the immune response, such as antigen recognition and the subsequent immune cell response. Researchers utilize ZAP-70 activators in laboratory settings to gain insights into immune cell signaling mechanisms, unravel the molecular basis of autoimmune diseases, and explore potential targets for drug development. These molecules serve as valuable tools to elucidate the complex web of cellular events that govern immune function and contribute to the advancement of our understanding of immunology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). It can indirectly induce ZAP-70 expression by activating PKC, which in turn activates various signaling pathways leading to increased transcription and translation of proteins involved in T-cell activation, including ZAP-70. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, plays a role in immune system regulation. It can influence ZAP-70 expression by modulating gene transcription and promoting the differentiation of T cells, enhancing their activation and function. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 has immunomodulatory effects and can influence T-cell function. It may indirectly enhance ZAP-70 expression by modulating immune responses and promoting the activation of T cells. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a synthetic corticosteroid with anti-inflammatory and immunosuppressive effects. It can influence ZAP-70 expression by modulating immune responses, potentially reducing T-cell activation in certain contexts. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a component of turmeric, has anti-inflammatory properties. It can modulate immune responses and potentially influence ZAP-70 expression by altering signaling pathways involved in T-cell activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound found in grapes and berries. It has anti-inflammatory and antioxidant properties and can modulate immune responses, potentially influencing ZAP-70 expression and T-cell function. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that has anti-inflammatory properties and can modulate gene expression. It may influence ZAP-70 expression by altering chromatin structure and gene transcription, potentially affecting T-cell activation and function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a major catechin found in green tea, with anti-inflammatory and antioxidant properties. It can modulate immune responses and potentially influence ZAP-70 expression, altering T-cell activation and function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is an essential trace element with a role in immune function. It can influence ZAP-70 expression by modulating various signaling pathways involved in T-cell activation, contributing to proper immune responses. | ||||||