YTHDF1 Inhibitors
Chemical inhibitors of YTHDF1 interfere with its ability to bind to m6A-modified RNA, a crucial aspect of its function in RNA metabolism. Rhodamine 6G, Methylene Blue, Chloroquine, Daunorubicin, Doxorubicin, and Ellipticine operate through a mechanism where they intercalate into RNA. This intercalation likely obstructs the binding sites on the RNA, preventing YTHDF1 from accessing its targets. Propidium Iodide shares a similar mode of action, inserting itself into the RNA structure and potentially competing with YTHDF1 for interaction with m6A sites. On the other hand, Eriochrome Black T utilizes a distinct approach by chelating metal ions, which are vital for the structural integrity and function of YTHDF1, thus impeding its RNA binding capability.
Aurintricarboxylic Acid acts by blocking the interaction between nucleic acids and proteins, thereby inhibiting the binding of YTHDF1 to m6A sites on RNA. Emetine engages in a different inhibitory strategy where it binds to ribosomal RNA, which may result in steric hindrance or induce conformational changes in the ribosomal RNA, leading to reduced interaction between YTHDF1 and its m6A-modified RNA targets. Mitoxantrone shares a mechanism similar to the intercalating agents but is distinct in its chemical structure. Actinomycin D, although not directly impeding YTHDF1's function, binds to DNA and hinders RNA transcription, which in turn could reduce the overall availability of RNA for YTHDF1 binding. Each of these chemicals, through their respective modes of action, disrupts the normal function of YTHDF1 in processing m6A-modified RNA molecules.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aurintricarboxylic Acid | 4431-00-9 | sc-3525 sc-3525A sc-3525B sc-3525C | 100 mg 1 g 5 g 10 g | $20.00 $32.00 $48.00 $94.00 | 13 | |
Aurintricarboxylic Acid is known to inhibit nucleic acid-protein interactions. It can inhibit YTHDF1 by preventing its binding to m6A sites on RNA, which is essential for YTHDF1's function in RNA metabolism. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $43.00 $104.00 $328.00 | 3 | |
Methylene Blue can inhibit YTHDF1 by intercalating into RNA, which may inhibit the binding of YTHDF1 to m6A-modified RNA, a critical interaction for its function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is known to intercalate into DNA and RNA, which can inhibit YTHDF1 by blocking its interaction with m6A-modified RNA, thus inhibiting its ability to regulate RNA metabolism. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $440.00 $900.00 $1400.00 $2502.00 | ||
Emetine can inhibit YTHDF1 by binding to ribosomal RNA, potentially preventing YTHDF1 from interacting with its target m6A-modified RNAs due to steric hindrance or conformational changes in the ribosomal RNA. | ||||||
Daunorubicin hydrochloride | 23541-50-6 | sc-200921 sc-200921A sc-200921B sc-200921C | 10 mg 50 mg 250 mg 1 g | $105.00 $438.00 $837.00 $1569.00 | 4 | |
Daunorubicin intercalates into DNA and RNA and can inhibit YTHDF1 by blocking the binding sites for YTHDF1 on m6A-modified RNAs, thus interfering with its function. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
Mitoxantrone intercalates into DNA and RNA and can inhibit YTHDF1's interaction with m6A-modified RNA by blocking the access of these RNAs to YTHDF1. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA and can inhibit YTHDF1 by preventing the transcription of RNA, thus indirectly reducing the amount of RNA available for YTHDF1 to bind to. This is a non-preferred method of inhibition that does not directly target the protein's function. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin, by intercalating into RNA, can inhibit YTHDF1 by preventing its binding to m6A-modified RNA, which is crucial for the protein's role in RNA metabolism. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $145.00 $569.00 | 4 | |
Ellipticine acts by intercalating into DNA and RNA, and can inhibit YTHDF1 by blocking its interaction with m6A-modified RNA, thereby inhibiting its function. | ||||||
Propidium Iodide | 25535-16-4 | sc-3541 sc-3541A | 50 mg 250 mg | $101.00 $296.00 | 168 | |
Propidium Iodide is a nucleic acid intercalator and can inhibit YTHDF1 by intercalating into RNA, thereby potentially competing with YTHDF1 for binding to m6A-modified RNA. | ||||||