XPG Activators
XPG (xeroderma pigmentosum group G) is a critical endonuclease involved in the nucleotide excision repair (NER) pathway, a mechanism essential for the repair of DNA lesions, particularly those induced by ultraviolet (UV) radiation, such as thymine dimers. The NER pathway is pivotal for maintaining genomic stability, preventing mutations that could lead to cancer and other genetic disorders. XPG specifically cleaves the damaged DNA strand at the 3' end of the lesion, facilitating the removal of a short single-stranded DNA segment containing the damage. This action allows for the subsequent filling in of the gap by DNA polymerase and ligation, thus restoring the DNA to its undamaged state. The function of XPG is not only crucial for repairing UV-induced DNA damage but also plays a role in the repair of other types of DNA lesions, contributing to the overall genomic integrity and cellular response to DNA damage.
The activation of XPG within the NER pathway involves several regulatory mechanisms that ensure its precise and timely action in response to DNA damage. Upon detection of DNA damage, XPG is recruited to the damaged site through interactions with other NER proteins, such as RPA, XPA, and TFIIH, which are involved in damage verification and the formation of the pre-incision complex. The recruitment and activation of XPG are tightly regulated by post-translational modifications, including phosphorylation and ubiquitination, which can influence its enzymatic activity, stability, and interactions with other NER components. Additionally, the cellular localization of XPG and its availability to participate in the NER process can be modulated by signaling pathways responsive to DNA damage, such as those involving the ATM and ATR kinases. These pathways help coordinate the cellular response to DNA damage, ensuring that XPG is activated in a context-dependent manner, thereby enabling the cell to efficiently repair DNA lesions and maintain genomic stability. This precise regulation of XPG activation is essential for the effective functioning of the NER pathway and the preservation of cellular health in response to genotoxic stress.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $49.00 $229.00 | 5 | |
Ethacrynic acid enhances XPG function by modulating the NF-κB pathway. It inhibits the activation of NF-κB, promoting XPG expression and activity in nucleotide excision repair through a direct influence on the cellular signaling pathway. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $31.00 $61.00 | 1 | |
Caffeic acid activates XPG by promoting p53-mediated pathways. It induces DNA damage and activates p53, leading to increased expression and recruitment of XPG in nucleotide excision repair processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol enhances XPG activity by activating the SIRT1 pathway. It stimulates SIRT1, leading to deacetylation of XPG and subsequent improvement of its function in nucleotide excision repair, thereby enhancing overall DNA repair efficiency. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic acid activates XPG by influencing the JNK pathway. It promotes JNK activation, leading to increased XPG expression and recruitment in nucleotide excision repair processes, ultimately enhancing its functional activity in repairing DNA lesions. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $46.00 $130.00 | 21 | |
Thymoquinone activates XPG through modulation of the MAPK pathway. It enhances ERK1/2 phosphorylation, leading to increased XPG expression and activity in nucleotide excision repair, thereby enhancing its efficiency in resolving DNA damage. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid enhances XPG function by influencing the AKT pathway. It activates AKT, leading to increased XPG expression and recruitment in nucleotide excision repair processes, ultimately improving its functional activity in repairing DNA lesions. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein enhances XPG activity by modulating the Wnt/β-catenin pathway. It inhibits β-catenin signaling, promoting XPG expression and activity in nucleotide excision repair through a direct influence on the cellular signaling pathway. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium orthovanadate activates XPG by influencing the PTEN pathway. It inhibits PTEN, leading to increased AKT activation, which in turn enhances XPG expression and recruitment in nucleotide excision repair processes, ultimately improving its functional activity. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $25.00 $80.00 $136.00 | 8 | |
Sodium salicylate activates XPG through modulation of the NF-κB pathway. It inhibits NF-κB activation, leading to increased XPG expression and recruitment in nucleotide excision repair processes, thereby enhancing its efficiency in resolving DNA damage. | ||||||