Wnt-4 Activators
Wnt-4 activators belong to a class of molecules that play a crucial role in the regulation of various developmental and tissue homeostasis processes in multicellular organisms. The term "Wnt-4" refers to a specific member of the Wnt protein family, which are secreted signaling molecules that orchestrate a wide range of cellular processes during embryonic development and adult tissue maintenance. Wnt-4, in particular, is known for its involvement in cell fate determination, tissue patterning, and organogenesis.
Wnt-4 activators are substances or mechanisms that enhance the activity of the Wnt-4 signaling pathway. Wnt-4 signals through a complex cascade of intracellular events, typically involving the activation of cell surface receptors and the subsequent regulation of gene expression. Activation of Wnt-4 signaling can have profound effects on cell behavior, including proliferation, differentiation, and migration, depending on the cellular context. This pathway is critical for various aspects of development, such as kidney development, mammary gland development, and sex determination in some species. By modulating the activity of Wnt-4, its activators contribute to the fine-tuning of these processes, ensuring the proper formation and maintenance of tissues and organs throughout an organism's life. In summary, Wnt-4 activators play an essential role in the complex regulatory network that governs embryonic development and tissue homeostasis, facilitating the precise control of cell behaviors that are vital for normal development and adult physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a plant-derived isoflavone that acts as an estrogen agonist. As Wnt-4 expression is sensitive to hormonal signaling, genistein exerts the potential to upregulate Wnt-4 transcription through binding to estrogen receptors during embryonic development and cell differentiation. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $71.00 $287.00 $547.00 $1098.00 $2185.00 | 3 | |
Diethylstilbestrol is a synthetic nonsteroidal estrogen used medically in the past. Similar to genistein, it may induce Wnt-4 through receptor-mediated pathways involving estrogen responsive elements in the Wnt-4 promoter or distant enhancers contributing to urogenital tract patterning. | ||||||
Bis(tributyltin) | 813-19-4 | sc-252469 | 10 g | $68.00 | ||
Bis(tributyltin) is an immunomodulating environmental contaminant. Acting through nuclear receptor signaling, it has the potential to perturb Wnt-4 expression levels as an embryotoxicant disrupting renal and reproductive organogenesis relying on fine-tuned Wnt pathway regulation. | ||||||
Pentadecafluorooctanoic acid | 335-67-1 | sc-250662 sc-250662A | 5 g 25 g | $50.00 $152.00 | ||
Pentadecafluorooctanoic acid is a endocrine-disrupting compound that impacts lipid and carbohydrate metabolism. Wnt-4 transcription is susceptible to altered nutrient sensing or energy homeostasis, implying Perfluorooctanoic acidmediated changes could influence its expression. | ||||||
Lead | 7439-92-1 | sc-250236 | 2 kg | $104.00 | ||
Lead is a developmental toxicant affecting multiple organ systems through interference with oxidative balance and enzymatic activities. Derangement of redox signaling mechanisms Wnt-4 responds to could lead to transcriptional changes in its levels. | ||||||