WFIKKN2 Activators

WFIKKN2 is a multi-domain protein that plays an intricate role in maintaining the extracellular matrix (ECM) and regulating tissue homeostasis. It contains a collection of protease domains, including WAP (whey acidic protein), Kazal, immunoglobulin, two Kunitz domains, and an NTR (netrin-like) module. These domains equip WFIKKN2 with the ability to inhibit various proteases, thus protecting tissues from excessive proteolysis, which is critical during inflammation, tissue repair, and in the context of diseases like cancer.Particularly, WFIKKN2 is known for its interaction with growth differentiation factor 8 (GDF8), or myostatin, a member of the transforming growth factor-beta (TGF-β) superfamily that negatively regulates skeletal muscle growth. WFIKKN2 can bind to myostatin, inhibiting its activity and thereby influencing muscle physiology and pathology.

Mutations in the WFIKKN2 gene have been linked to certain muscle and skeletal disorders, highlighting its significance in muscle development and maintenance. The study of WFIKKN2 has implications, especially in conditions where modulation of ECM components and protease activity is beneficial.WFIKKN2's broad array of domains indicates a role as a master regulator of proteolytic activity in the ECM.