WFIKKN2 Activators
WFIKKN2 is a multi-domain protein that plays an intricate role in maintaining the extracellular matrix (ECM) and regulating tissue homeostasis. It contains a collection of protease domains, including WAP (whey acidic protein), Kazal, immunoglobulin, two Kunitz domains, and an NTR (netrin-like) module. These domains equip WFIKKN2 with the ability to inhibit various proteases, thus protecting tissues from excessive proteolysis, which is critical during inflammation, tissue repair, and in the context of diseases like cancer.Particularly, WFIKKN2 is known for its interaction with growth differentiation factor 8 (GDF8), or myostatin, a member of the transforming growth factor-beta (TGF-β) superfamily that negatively regulates skeletal muscle growth. WFIKKN2 can bind to myostatin, inhibiting its activity and thereby influencing muscle physiology and pathology.
Mutations in the WFIKKN2 gene have been linked to certain muscle and skeletal disorders, highlighting its significance in muscle development and maintenance. The study of WFIKKN2 has implications, especially in conditions where modulation of ECM components and protease activity is beneficial.WFIKKN2's broad array of domains indicates a role as a master regulator of proteolytic activity in the ECM.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can affect GSK-3 activity and Wnt signaling, pathways that may regulate the expression of ECM components like WFIKKN2. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid that can modulate inflammation and tissue response, potentially increasing WFIKKN2 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid affects gene transcription through retinoic acid receptors, which may influence WFIKKN2 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates Nrf2, a transcription factor that could enhance the expression of protective proteins in tissues. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has anti-inflammatory and antioxidant properties that may influence the expression of ECM-related proteins. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may activate SIRT1 and AMPK, pathways potentially involved in ECM protein regulation. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone is a PPAR-gamma agonist that can influence tissue metabolism and protein expression. | ||||||
3,4-Dihydroxyphenyl Ethanol | 10597-60-1 | sc-202887 | 10 mg | $110.00 | 6 | |
Hydroxytyrosol, an antioxidant, could impact signaling pathways related to tissue protection and ECM proteins. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic acid is vital for collagen synthesis and might influence the expression of other ECM proteins. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc sulfate is important for many enzymatic processes and could play a role in gene expression and ECM stability. | ||||||