WDR88 Activators
WDR88 can initiate a cascade of intracellular events leading to its activation through various molecular mechanisms. Forskolin, a diterpene, acts directly on adenylate cyclase, thereby increasing intracellular levels of cyclic AMP (cAMP), a secondary messenger that plays a pivotal role in the activation of proteins. Elevated cAMP can enhance the function of proteins like WDR88 by promoting phosphorylation or changes in protein conformation. Similarly, IBMX, a non-specific inhibitor of phosphodiesterases, prevents the breakdown of cAMP, resulting in sustained activation signals that may involve WDR88. In this context, 8-Bromo-cAMP, a cell-permeable analog of cAMP, mimics the natural messenger by directly stimulating cAMP-dependent pathways, which could lead to the direct activation of WDR88.
PMA (Phorbol 12-Myristate 13-Acetate) and Chelerythrine act on protein kinase C (PKC), a family of enzymes that phosphorylate serine and threonine residues on target proteins. PMA functions as an activator of PKC, potentially leading to the phosphorylation and subsequent activation of WDR88. In contrast, Chelerythrine is a PKC inhibitor, but the resulting disruption in phosphorylation equilibrium can lead to alternative activation routes for proteins like WDR88. Okadaic Acid and Calyculin A, inhibitors of protein phosphatases 1 and 2A, cause an increase in phosphorylation levels within cells, which could lead to the activation of proteins such as WDR88. Lithium Chloride, by inhibiting glycogen synthase kinase-3 (GSK-3), may stabilize and activate proteins within the same pathway as WDR88. Anisomycin, a protein synthesis inhibitor, triggers stress response pathways that could involve the activation of WDR88 through post-translational modifications. Lastly, Zaprinast, though primarily affecting cGMP-specific phosphodiesterases, can influence cAMP pathways as well, which may implicate the activation of WDR88.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing levels of cAMP, which is a secondary messenger that can enhance the function of various proteins including WDR88 by promoting its phosphorylation or change in conformation for activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, thereby preventing the breakdown of cAMP and indirectly sustaining its activation potential, which can lead to the activation of proteins associated with the cAMP pathway including WDR88. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate target proteins. As part of a signaling pathway, the PKC-mediated phosphorylation can lead to the activation of WDR88. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is an inhibitor of protein phosphatases 1 and 2A, resulting in increased phosphorylation levels within the cell, which could lead to the activation of WDR88 through enhanced phosphorylation status. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits glycogen synthase kinase-3 (GSK-3), which may result in the stabilization and activation of proteins downstream or within pathways where WDR88 functions. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate is known to inhibit various protein kinases, which could shift the balance of kinase and phosphatase activities in the cell, potentially leading to the activation of WDR88. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor, which can lead to the activation of stress response pathways and could activate proteins involved in these pathways, including WDR88, through post-translational modifications. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases, particularly PP1 and PP2A, like Okadaic Acid, and can similarly lead to increased phosphorylation and potential activation of WDR88. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that directly activates cAMP-dependent pathways, leading to the activation of proteins that are part of these pathways, potentially including WDR88. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast is a selective inhibitor of cGMP-specific phosphodiesterases. While primarily impacting cGMP levels, perturbations in cGMP can affect cAMP pathways as well, possibly leading to the activation of WDR88. | ||||||