Vmn2r118 Inhibitors
Vmn2r118 inhibitors refer to a specific category of compounds that interact with the Vmn2r118 receptor, which is a part of a larger family of receptors known as vomeronasal type-2 receptors (V2Rs). V2Rs are a group of G protein-coupled receptors (GPCRs) that are predominantly found in the vomeronasal organ (VNO) of certain mammals. The VNO is an olfactory structure that is involved in the detection of pheromones, chemical signals that are often associated with social and reproductive behaviors. Each receptor in this family is encoded by a distinct gene and is responsible for recognizing specific molecular cues. Vmn2r118 inhibitors, therefore, are molecules that specifically bind to and inhibit the function of the Vmn2r118 receptor, blocking its ability to interact with its natural ligands.
The molecular interactions between Vmn2r118 inhibitors and the Vmn2r118 receptor are characterized by the binding of the inhibitor to the receptor's active site or other relevant binding sites, which prevents the receptor from undergoing the conformational changes typically induced by its natural ligands. This inhibition can alter the signaling pathways that are normally activated by the binding of ligands to Vmn2r118, leading to a suppression of the receptor's activity. The design of these inhibitors is often guided by the structural understanding of the receptor, aiming to achieve a high degree of specificity to avoid off-target effects on other V2R family members or unrelated GPCRs. Inhibitors can be small organic molecules, peptides, or other types of chemical entities that possess the necessary characteristics to interact with the receptor with sufficient affinity and selectivity to effectively inhibit its function. The study of Vmn2r118 and its inhibitors can contribute to the broader understanding of the molecular mechanisms underlying the sense of smell and pheromone detection in mammals, shedding light on the complex network of interactions that drive animal behavior at the chemical level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is an inhibitor of ADP-ribosylation factor (ARF), which is a small GTPase involved in vesicle trafficking between the Golgi and the endoplasmic reticulum. By disrupting vesicle-mediated transport, Brefeldin A can indirectly inhibit Vmn2r118 by affecting the trafficking of the receptor to the membrane surface. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. It can indirectly inhibit Vmn2r118 by blocking the phosphorylation of proteins involved in the signaling pathways that may be responsible for the receptor's internalization and recycling processes. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin irreversibly ADP-ribosylates the alpha subunit of certain G proteins, which prevents their interaction with GPCRs. As Vmn2r118 is a GPCR, pertussis toxin can indirectly inhibit its signaling by preventing G protein coupling. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $119.00 $364.00 $947.00 | 17 | |
Concanavalin A is a lectin that binds to glycoproteins and can cluster glycosylated receptors, potentially leading to their internalization and degradation. Vmn2r118, if glycosylated, could be indirectly inhibited by this process. | ||||||
Clozapine | 5786-21-0 | sc-200402 sc-200402A sc-200402B sc-200402C | 50 mg 500 mg 5 g 10 g | $69.00 $364.00 $2500.00 $4100.00 | 11 | |
Clozapine is an antagonist of various neurotransmitter receptors and can indirectly inhibit Vmn2r118 by modulating neural circuits involved in the processing of pheromonal information that the receptor may detect and relay. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK). By inhibiting MLCK, it can alter the actin cytoskeleton dynamics, affecting the trafficking and surface expression of GPCRs, thus indirectly affecting Vmn2r118 function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a small molecule that inhibits dynamin, a GTPase involved in vesicle scission during endocytosis. This can indirectly inhibit Vmn2r118 by preventing the receptor's internalization and recycling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Ly294002 is a potent inhibitor of the phosphoinositide 3-kinases (PI3K). It can indirectly inhibit Vmn2r118 by affecting the PI3K/AKT signaling pathway, which is involved in many cellular processes including receptor trafficking and signaling. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go 6983 is a broad-spectrum protein kinase C (PKC) inhibitor. As PKC plays a role in regulating GPCR signaling, Go 6983 could indirectly inhibit Vmn2r118 by reducing the phosphorylation and regulation of the receptor's activity. | ||||||