Vinexin Activators
Vinexin activators comprise a class of chemical compounds that modulate the activity of the Vinexin protein, which is involved in various intracellular signaling pathways. Vinexin, a scaffolding protein, typically possesses a sorbin homology (SoHo) domain and three SH3 domains that facilitate its interactions with other proteins, thus influencing processes such as cytoskeletal organization, cell adhesion, and growth factor signaling.
The precise mechanism by which Vinexin activators exert their effect can vary, but generally, these activators can bind directly to Vinexin, altering its conformation and thereby modulating its interactions with other proteins. This can result in an enhanced binding affinity for certain signaling molecules or an increased ability to localize to specific cellular compartments where Vinexin exerts its effects. Alternatively, Vinexin activators may function indirectly by modulating the signaling pathways that regulate Vinexin or by affecting the post-translational modifications of Vinexin, which can influence its activity and stability. By activating Vinexin, these chemicals can potentially affect a multitude of cellular functions. Understanding the precise biochemical interactions and the resultant cellular consequences of Vinexin activation is a subject of research interest, as it provides insight into the intricate web of cellular signaling networks and their regulation.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), a known regulator of Vinexin's activity. PKC can enhance the phosphorylation of Vinexin, leading to its activation and increased interaction with other proteins. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1, like PMA, is a PKC activator. It can lead to the phosphorylation and subsequent activation of Vinexin, enhancing its ability to interact with other proteins in the cell. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine, by binding to adrenergic receptors, can trigger an increase in cAMP levels. The increased cAMP can lead to the activation of PKA, which has been implicated in the phosphorylation and activation of Vinexin. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cAMP. The elevated cAMP activates PKA, which can phosphorylate and activate Vinexin. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, activating PKA. PKA can then phosphorylate and activate Vinexin, enhancing its activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterases, leading to an increase in cAMP levels, which can activate PKA, potentially leading to the phosphorylation and activation of Vinexin. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol inhibits PDE3 and increases cAMP levels, thus activating PKA. PKA can then phosphorylate and activate Vinexin. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits protein phosphatases PP1 and PP2A, which are involved in dephosphorylation events. This can enhance the phosphorylation state of Vinexin, hence promoting its activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A inhibits protein phosphatases PP1 and PP2A, maintaining proteins, like Vinexin, in their phosphorylated states, and enhancing their activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterases, resulting in increased cAMP levels. This can activate PKA and potentially lead to phosphorylation and activation of Vinexin. | ||||||