Vac17p Activators
Vac17p activators encompass a diverse array of chemical agents that facilitate the vacuole inheritance process by modulating the cytoskeletal components and associated proteins directly involved with Vac17p function. This chemical class includes compounds that can stabilize actin filaments, such as jasplakinolide and phallacidin, ensuring the structural integrity of actin cables that are essential for vacuole transport. Others, like swinholide A, act on the dynamic equilibrium of actin polymerization and depolymerization, potentially providing a means to fine-tune the cytoskeletal architecture necessary for Vac17p-mediated vacuole inheritance. Additionally, agents such as MLCK inhibitor peptide 18 and blebbistatin offer modulation of myosin function, which may enhance the interaction between Vac17p and the motor protein MYO2, central to the vacuole movement mechanism. Through their action on actin and myosin, these compounds collectively function to support the processes underlying the vacuole's proper positioning within a cell.
The Vac17p activator class is not limited to agents acting solely on actin dynamics but also includes molecules like calyculin A, which alters protein phosphorylation states, potentially impacting the assembly of the vacuole transport complex. The chemical profiles of such activators are characterized by their ability to interact with cellular proteins and modify their activity, leading to downstream effects on Vac17p function. Furthermore, some compounds, such as mevastatin and paclitaxel, while not directly linked to actin or myosin regulation, are included due to their capacity to influence cellular transport mechanisms and cytoskeletal components
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
A cyclodepsipeptide that stabilizes actin filaments and promotes actin polymerization. This could enhance the transport complex's ability to move vacuoles along actin cables by ensuring that the cables are robust and capable of supporting movement. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
A bis-lactone that severs actin filaments and caps the barbed ends, which can result in the rapid polymerization of monomeric actin to replenish the filaments. This can indirectly maintain a pool of actin for polymerization and assist in vacuole movement mediated by Vac17p. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
An inhibitor of myosin II ATPase activity, which can modulate the function of myosin motors and might influence the transport of vacuoles in a manner dependent on Vac17p's interaction with Myo2. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
A small molecule inhibitor of formin homology 2 domains, which could alter the polymerization of actin and influence the transport process of vacuoles along actin cables, potentially impacting Vac17p activity. | ||||||
Phallacidin | 26645-35-2 | sc-204840 | 1 mg | $209.00 | 4 | |
Binds to and stabilizes actin filaments, and by preventing depolymerization, it could support the actin structures required for Vac17p function. | ||||||
Mevastatin (Compactin) | 73573-88-3 | sc-200853 sc-200853A | 10 mg 50 mg | $77.00 $179.00 | 18 | |
An HMG-CoA reductase inhibitor that might influence the prenylation and thereby the function of proteins involved in actin cable formation or maintenance, which could affect the transport complex involving Vac17p. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules, but its influence on the cytoskeletal dynamics can have broader effects on cellular transport mechanisms, potentially affecting Vac17p-associated vacuole movement indirectly. | ||||||