USP5 Activators
Ubiquitin Specific Protease 5 (USP5) plays a pivotal role in the regulation of ubiquitin homeostasis, a critical process for maintaining protein quality control within the cell. USP5's primary function involves the cleavage of unanchored polyubiquitin chains, thus regulating the availability of free ubiquitin and ensuring the proper execution of ubiquitin-dependent signaling pathways. This regulatory mechanism is essential for a wide range of cellular processes, including protein degradation, cell cycle control, DNA repair, and signal transduction, underscoring the importance of USP5 in cellular physiology and stress response mechanisms.
Activation of USP5 is a complex process that involves its interaction with various cellular components and pathways. Given the absence of well-characterized direct activators, the chemicals listed are proposed to indirectly influence USP5 activity through their effects on related cellular pathways. These compounds, through their diverse biological activities, are hypothesized to create cellular conditions that favor the stabilization, expression, or functional enhancement of USP5. This indirect activation could be mediated by mechanisms such as the modulation of cellular stress responses, activation of antioxidant defense systems, regulation of proteostasis, and maintenance of the ubiquitin-proteasome system. By stabilizing the cellular environment and ensuring the efficient regulation of ubiquitin dynamics, these chemicals may contribute to the optimal functioning of USP5, highlighting the intricate interplay between USP5 and various cellular processes essential for maintaining cellular homeostasis and responding to cellular stress.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol enhances the deubiquitination process by modulating cellular stress pathways, leading to the stabilization and potential activation of USP5. This activation promotes the maintenance of protein homeostasis and regulates ubiquitin levels. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates NRF2 signaling, a pathway known to induce the expression of antioxidant response elements. Enhanced NRF2 activity may indirectly increase USP5 activity by creating an environment that favors its stabilizing deubiquitinating functions. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin influences multiple signaling pathways, including NF-κB, which is linked to the regulation of inflammation and cellular stress responses. Through modulation of these pathways, curcumin can indirectly promote USP5 activity, aiding in the regulation of ubiquitin dynamics. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, impacts cellular signaling pathways that are involved in oxidative stress responses. By modulating these pathways, EGCG can indirectly support USP5 activation, contributing to the cellular defense mechanism. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine activates cellular stress responses, potentially leading to an indirect activation of USP5 by enhancing its role in the maintenance of proteostasis and the regulation of the ubiquitin-proteasome system. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin modulates signaling pathways that control cellular stress and inflammation. Through these pathways, quercetin can indirectly enhance USP5 activity, contributing to the regulation of ubiquitin-dependent protein degradation. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Withaferin A, by modulating stress response pathways and inhibiting NF-κB, can indirectly enhance USP5 activity. This promotes the regulation of ubiquitin levels and aids in maintaining cellular protein quality control. | ||||||
Honokiol | 35354-74-6 | sc-202653 sc-202653A | 10 mg 25 mg | $118.00 $178.00 | 4 | |
Honokiol influences cellular pathways related to stress and survival, indirectly supporting USP5 activation. This contributes to the regulation of the ubiquitin system and assists in cellular protection mechanisms. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine promotes autophagy, a process that can indirectly lead to the activation of USP5 by enhancing the clearance of ubiquitinated proteins and maintaining cellular homeostasis. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Ursolic Acid modulates pathways involved in cellular stress responses and inflammation. This modulation can indirectly activate USP5, contributing to the regulation of ubiquitin levels and proteostasis. | ||||||