UIMC1 Inhibitors
Chemical inhibitors of UIMC1 function by disrupting several key processes within the DNA damage response and repair pathways. Camptothecin, for example, is a topoisomerase I inhibitor that can impede UIMC1's role in the DNA repair process. Given that UIMC1 is part of the BRCA1-A complex, which interacts with topoisomerase I, the inhibition of this enzyme leads to a decrease in the repair of DNA damage, a process where UIMC1 is involved. Similarly, etoposide and teniposide, which target topoisomerase II, also indirectly cause an accumulation of DNA damage, thus affecting UIMC1's function. These topoisomerase II inhibitors create a hostile environment for UIMC1's activity by preventing the ligation of DNA strands, which is essential for the repair of double-strand breaks.
Other inhibitors, such as mitoxantrone and amsacrine, which are known to intercalate into DNA and inhibit topoisomerase II, further exacerbate the inhibition of UIMC1. Their intercalative properties lead to the obstruction of the transcription and replication processes, thereby impeding the DNA repair function where UIMC1 is implicated. Actinomycin D operates by binding to DNA and inhibiting RNA polymerase, thus disrupting the transcription of DNA repair genes and consequently inhibiting UIMC1 function. Aphidicolin adds to this collection of inhibitors by targeting DNA polymerases, leading to disruptions in DNA replication forks, a process that UIMC1 is known to be involved in. Brefeldin A's unique mechanism of disrupting protein transport indirectly impacts UIMC1 by potentially affecting its localization and function within the DNA damage response pathway. Additionally, the PI3K inhibitors wortmannin and LY294002 disrupt the PI3K signaling pathway, which indirectly affects UIMC1 through the inhibition of PIKK family members like ATM and ATR that regulate UIMC1's activity. Finally, inhibitors such as Nu7441 and KU55933, which target DNA-PK and ATM respectively, impede the non-homologous end-joining pathway and ATM-regulated processes, both of which are crucial for UIMC1's involvement in resolving DNA damage.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin, a topoisomerase I inhibitor, can inhibit UIMC1 as UIMC1 is a component of the BRCA1-A complex which interacts with and is regulated by topoisomerase I. Inhibition of topoisomerase I leads to decreased repair of DNA damage, which is a process UIMC1 is involved in. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide targets topoisomerase II, which works in concert with topoisomerase I to facilitate DNA unwinding. By inhibiting topoisomerase II, etoposide indirectly causes an accumulation of DNA damage and inhibits the DNA repair function of UIMC1 as it is part of the BRCA1-A complex which is involved in DNA damage response. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Mitoxantrone is an anthracenedione that intercalates into DNA and inhibits topoisomerase II. By disrupting the DNA repair process through topoisomerase II inhibition, mitoxantrone can indirectly inhibit the function of UIMC1, which is involved in the DNA damage response as a component of the BRCA1-A complex. | ||||||
Amsacrine hydrochloride | 54301-15-4 | sc-214540 | 10 mg | $232.00 | ||
Amsacrine is another topoisomerase II inhibitor that intercalates DNA and can inhibit the DNA repair function of UIMC1 indirectly by preventing the repair of double-strand breaks where UIMC1 is involved as part of the BRCA1-A complex. | ||||||
Teniposide | 29767-20-2 | sc-204910 sc-204910A | 25 mg 100 mg | $72.00 $230.00 | 6 | |
Teniposide functions similarly to etoposide by inhibiting topoisomerase II, leading to an indirect inhibition of UIMC1's role in the DNA damage response pathway and the repair of double-strand breaks. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA polymerase, leading to a disruption in the transcription of DNA repair genes. This action can inhibit the function of UIMC1, which is involved in the DNA damage response that requires transcription of several repair factors. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin is a DNA polymerase inhibitor that can indirectly inhibit UIMC1 by disrupting the DNA replication fork progression, which is a process where UIMC1 is involved in the resolution and repair of stalled forks as part of the BRCA1-A complex. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts protein transport by inhibiting the exchange of guanine nucleotide on ARFs, which may indirectly impact the localization and function of UIMC1 in the DNA damage response, particularly affecting its role in the repair and signaling pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of the phosphoinositide 3-kinases (PI3K) family, which indirectly inhibits UIMC1 by affecting the PI3K-related kinase (PIKK) family members such as ATM and ATR that regulate UIMC1 function in response to DNA damage. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor that indirectly inhibits UIMC1 by disrupting PI3K signaling, thereby affecting the function of PIKK family members like ATM and ATR that are upstream regulators of UIMC1 in the DNA damage repair pathway. | ||||||