UGT Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
D-Limonene is a monoterpene that exhibits unique interactions with UDP-glucuronosyltransferases (UGTs), influencing their substrate specificity. Its hydrophobic nature facilitates binding to the enzyme's active site, potentially altering the conformation and enhancing glucuronidation rates. The compound's stereochemistry may also affect the kinetics of UGT-mediated reactions, leading to variations in metabolic pathways. Furthermore, D-Limonene's presence can modulate membrane fluidity, impacting enzyme accessibility and activity. | ||||||
(±)-Sulfinpyrazone | 57-96-5 | sc-202822 sc-202822A | 1 g 5 g | $42.00 $94.00 | 2 | |
(±)-Sulfinpyrazone is a sulfinyl compound that interacts with UDP-glucuronosyltransferases (UGTs) through specific hydrogen bonding and steric effects, influencing enzyme activity. Its unique chiral centers can lead to differential binding affinities, affecting glucuronidation efficiency. The compound's electron-withdrawing sulfinyl group may enhance reactivity, while its rigid structure can stabilize enzyme-substrate complexes, potentially altering metabolic flux and pathway dynamics. | ||||||
Phloxine B | 18472-87-2 | sc-203753 sc-203753A sc-203753B sc-203753C | 25 g 100 g 250 g 1 kg | $58.00 $162.00 $298.00 $922.00 | 1 | |
Phloxine B is a synthetic dye that exhibits unique interactions with UDP-glucuronosyltransferases (UGTs) through hydrophobic and electrostatic forces, influencing substrate binding. Its planar aromatic structure allows for π-π stacking with aromatic residues in the enzyme, enhancing binding affinity. Additionally, the presence of halogen substituents can modulate electronic properties, potentially affecting reaction kinetics and the overall glucuronidation process, thereby impacting metabolic pathways. | ||||||