UBPY Activators

UBPY Activators are a class of chemical compounds that can enhance the functional activity of UBPY, a deubiquitinating enzyme. The functional activity of UBPY is enhanced when the intracellular levels of ubiquitinated proteins are increased. This increase can be achieved by inhibiting autophagy or proteasome pathways, or by inhibiting other DUBs. For instance, autophagy inhibitors such as Chloroquine, 3-Methyladenine, and Bafilomycin A1 work by inhibiting the degradation of ubiquitinated proteins, thereby increasing their concentration and providing UBPY with more substrates to act upon.

Proteasome inhibitors like MG132 and Lactacystin also increase the concentration of ubiquitinated proteins by inhibiting their degradation in the proteasome. Similarly, inhibitors of other DUBs, like Spautin-1 (which inhibits USP10 and USP13), PR-619 (a broad-spectrum DUB inhibitor), and IU1 (a specific USP14 inhibitor), enhance the activity of UBPY by increasing the concentration of ubiquitinated proteins. Eeyarestatin I, an ERAD inhibitor, and Pyr-41, an irreversible ubiquitin-activating enzyme E1 inhibitor, enhance UBPY's activity by increasing the accumulation of ubiquitinated proteins.