Date published: 2025-9-27

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Tyrosinase Inhibitors

Tyrosinase is an enzyme that plays a pivotal role in the biosynthesis of melanin, the pigment responsible for the coloration of skin, hair, and eyes in humans and other organisms. This enzyme is a copper-containing protein primarily found in melanocytes, specialized cells located in the epidermis, hair follicles, and eyes. Its central function is to catalyze the rate-limiting step in melanin production, which involves the conversion of tyrosine, an amino acid, into dopaquinone. Subsequently, dopaquinone undergoes a series of chemical reactions leading to the formation of melanin pigments, which provide protection against the harmful effects of ultraviolet (UV) radiation and contribute to various physiological processes, including photoprotection, camouflage, and signaling. Structurally, tyrosinase consists of two copper atoms per molecule, situated at the active site, where the enzyme's catalytic activity takes place. The enzyme undergoes a complex process of activation, involving the insertion of copper ions into its structure to facilitate its enzymatic functions. Tyrosinase is a key player in the regulation of melanin synthesis, which is vital for the determination of skin and hair color, as well as for protecting the skin from UV-induced damage. Its importance extends beyond pigmentation, as abnormal tyrosinase activity is associated with various dermatological conditions and disorders. Tyrosinase Inhibitors represent a chemical class of compounds designed to selectively target and modulate the activity of tyrosinase. These inhibitors are typically small molecules or compounds engineered to interfere with tyrosinase's catalytic function, disrupting its ability to convert tyrosine into dopaquinone and subsequently impeding melanin synthesis.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Anacardic Acid

16611-84-0sc-202463
sc-202463A
5 mg
25 mg
$100.00
$200.00
13
(1)

Anacardic Acid acts as a potent inhibitor of tyrosinase, engaging in specific interactions that disrupt the enzyme's catalytic activity. Its unique structure allows for competitive binding at the active site, effectively blocking substrate access. The compound's ability to form hydrogen bonds and hydrophobic interactions with key amino acid residues enhances its inhibitory potency. Additionally, Anacardic Acid exhibits a favorable kinetic profile, characterized by a rapid onset of inhibition, making it a compelling candidate for modulating enzymatic reactions.

Aloesin

30861-27-9sc-202450
1 mg
$262.00
1
(1)

Aloesin, derived from Aloe vera, can inhibit tyrosinase activity, thus reducing melanin production.

L-Mimosine

500-44-7sc-201536A
sc-201536B
sc-201536
sc-201536C
25 mg
100 mg
500 mg
1 g
$35.00
$86.00
$216.00
$427.00
8
(2)

L-Mimosine is a notable tyrosinase inhibitor, characterized by its ability to chelate copper ions essential for the enzyme's activity. This interaction alters the enzyme's conformation, leading to a significant reduction in its catalytic efficiency. The compound's unique side chains facilitate specific non-covalent interactions with the enzyme, enhancing its inhibitory effects. Furthermore, L-Mimosine demonstrates a distinct reaction kinetics profile, exhibiting a delayed onset of inhibition that allows for nuanced modulation of enzymatic pathways.

5-Hydroxyindole

1953-54-4sc-254834
sc-254834A
1 g
5 g
$57.00
$130.00
(0)

5-Hydroxyindole acts as a potent tyrosinase substrate, engaging in specific interactions with the enzyme's active site. Its structural features promote effective binding, facilitating the conversion of L-tyrosine to melanin precursors. The compound exhibits unique reaction kinetics, characterized by a rapid initial phase followed by a slower steady-state, allowing for intricate regulation of melanin synthesis. Additionally, its ability to stabilize enzyme intermediates enhances the overall catalytic process.

Arbutin

497-76-7sc-221267
sc-221267A
10 g
25 g
$118.00
$237.00
(0)

Arbutin is a naturally occurring derivative of hydroquinone and acts by inhibiting tyrosinase, thereby reducing melanin production.

Rubrofusarin

3567-00-8sc-364132
5 mg
$460.00
(0)

Rubrofusarin serves as a unique tyrosinase substrate, exhibiting distinct molecular interactions that enhance its binding affinity to the enzyme's active site. Its structural conformation allows for effective electron transfer during the oxidation of phenolic compounds, influencing reaction kinetics. The compound's ability to form stable enzyme-substrate complexes leads to a pronounced effect on the rate of melanin production, showcasing its role in modulating enzymatic activity through specific conformational changes.

(R)-6-Methoxy-2,5,7,8-tetramethylchromane-2-carboxylic acid

139658-04-1sc-229123
50 mg
$123.00
(0)

(R)-6-Methoxy-2,5,7,8-tetramethylchromane-2-carboxylic acid acts as a distinctive tyrosinase inhibitor, characterized by its ability to disrupt the enzyme's catalytic cycle. Its unique steric configuration facilitates competitive inhibition, altering substrate accessibility. The compound's hydrophobic interactions with the enzyme's active site contribute to a significant reduction in reaction velocity, highlighting its potential to modulate enzymatic pathways through structural interference.