TTLL8 Activators
The chemical class of TTLL8 activators primarily includes compounds that indirectly influence the activity of Tubulin Tyrosine Ligase-Like Family Member 8 (TTLL8), a protein involved in post-translational modification of tubulin, specifically polyglutamylation. This modification is crucial for the proper functioning of microtubules in cellular processes. The activators in this class do not interact directly with TTLL8 but exert their influence through the modulation of microtubule dynamics and tubulin states, thereby indirectly affecting TTLL8's functional role in the cell.
The activators, including microtubule-stabilizing agents like Taxol and Epothilone B, and microtubule-destabilizing agents like Vinblastine, Nocodazole, and Colchicine, impact microtubule dynamics. Stabilizing agents increase the rigidity and stability of microtubules, enhancing the substrate availability or interaction context for TTLL8. On the other hand, destabilizing agents lead to disassembly or altered polymerization of microtubules, which could indirectly influence TTLL8 activity by creating a cellular environment where tubulin polyglutamylation processes are altered, either through compensatory mechanisms or through changes in tubulin availability and structure.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules, which could indirectly affect TTLL8 activity by influencing microtubule dynamics and tubulin modification processes. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B stabilizes microtubules similarly to Taxol, potentially influencing TTLL8 activity indirectly by affecting microtubule dynamics. | ||||||
Colcemid | 477-30-5 | sc-202550A sc-202550 sc-202550B sc-202550C sc-202550D sc-202550E | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg | $68.00 $162.00 $318.00 $947.00 $1893.00 $6840.00 | 7 | |
Demecolcine disrupts microtubules, potentially influencing TTLL8 activity by affecting microtubule dynamics and tubulin modification processes. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
Laulimalide stabilizes microtubules, potentially influencing TTLL8 indirectly by affecting tubulin dynamics and microtubule stability. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits microtubule assembly, potentially influencing TTLL8 activity by altering microtubule dynamics and tubulin modifications. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $46.00 $81.00 | ||
Combretastatin A-4 inhibits microtubule assembly, potentially affecting TTLL8 activity indirectly through altered tubulin dynamics. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
2-Methoxyestradiol disrupts microtubule networks, which could indirectly influence TTLL8 by affecting tubulin dynamics and polyglutamylation processes. | ||||||