TSHZ3 Inhibitors
TSHZ3 inhibitors belong to a specialized class of chemical compounds designed to interact with and modulate the activity of the TSHZ3 protein within biological systems. TSHZ3, or teashirt zinc finger homeobox 3, is a transcription factor that plays a pivotal role in the regulation of gene expression during development and tissue differentiation. It belongs to the teashirt family of transcription factors, characterized by the presence of zinc finger domains that bind to specific DNA sequences, thus influencing the activation or repression of target genes. TSHZ3 inhibitors are designed to selectively target TSHZ3, either by directly binding to the protein or by interfering with its DNA-binding capabilities, with the aim of regulating specific cellular and developmental processes related to gene expression and tissue patterning.
The development and study of TSHZ3 inhibitors are driven by the increasing recognition of TSHZ3's significance in embryogenesis, tissue differentiation, and organogenesis. TSHZ3 plays a critical role in orchestrating the transcriptional programs that govern cell fate determination and tissue-specific functions. By modulating the activity of TSHZ3, these inhibitors provide a valuable tool for researchers to investigate the molecular mechanisms underlying gene regulation and developmental processes. Researchers in this field are continually exploring novel chemical compounds and strategies to fine-tune TSHZ3 inhibition, aiming to uncover new insights into the intricate genetic networks that drive cellular differentiation and tissue development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA, inhibiting RNA synthesis. By blocking transcription, it could potentially decrease TSHZ3 expression. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $311.00 | ||
This compound inhibits cyclin-dependent kinases, which are essential for cell cycle progression. By affecting cell cycle, it might indirectly affect transcriptional regulators like TSHZ3. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $110.00 $386.00 | 8 | |
A platinum-based compound that can cause DNA crosslinking, potentially affecting transcription and thereby TSHZ3 expression. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
By inhibiting topoisomerase II, etoposide affects DNA topology and can influence transcription, potentially affecting TSHZ3 expression. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
This compound inhibits NF-κB activation. If TSHZ3 is co-regulated or interacts with NF-κB pathways, its expression might be affected. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can impact protein turnover and might indirectly influence TSHZ3 stability or expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Inhibits RNA polymerase II, directly affecting mRNA transcription and potentially decreasing TSHZ3 expression. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Inhibits NF-κB and might have broader effects on transcriptional regulators, potentially influencing TSHZ3. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
By inhibiting topoisomerase I, camptothecin affects DNA topology, potentially influencing transcription and TSHZ3 expression. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $63.00 $179.00 | 11 | |
A histone deacetylase inhibitor that can alter gene expression. Its effects might include modulation of TSHZ3. | ||||||