TS Activators
The class of TS activators encompasses a group of chemicals that indirectly support the activity of thymidylate synthase (TS), a critical enzyme involved in DNA biosynthesis, by influencing various pathways and cellular processes crucial for thymidine biosynthesis and DNA replication. Folate (Vitamin B9) plays a central role in TS activation by serving as a fundamental cofactor in the one-carbon metabolism pathway. Folate is converted into active forms such as tetrahydrofolate (THF), which donates one-carbon units essential for the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) by TS. Methionine, another essential amino acid, indirectly activates TS by contributing to the one-carbon metabolism pathway. Methionine acts as a methyl donor in the conversion of homocysteine to methionine, a process essential for the synthesis of THF, a critical cofactor for TS.
Vitamin B12 (cobalamin) is another key player in TS activation through its involvement in the one-carbon metabolism pathway. Vitamin B12 acts as a cofactor for methionine synthase, an enzyme that converts homocysteine to methionine. Methionine, in turn, contributes to the synthesis of THF, a crucial cofactor for TS. Thymidine, a deoxyribonucleoside, directly supports TS activity by providing a direct substrate for the enzyme. TS catalyzes the conversion of dUMP to dTMP using thymidine as a precursor. Serine, an amino acid, indirectly activates TS through its involvement in the one-carbon metabolism pathway. Serine contributes methyl groups, which are essential for the synthesis of THF, a critical cofactor for TS-mediated thymidine biosynthesis. Pyridoxal Phosphate (Vitamin B6), also known as vitamin B6, indirectly activates TS by participating in one-carbon metabolism. It facilitates the conversion of serine to glycine, a reaction that generates one-carbon units used in the synthesis of THF, a crucial cofactor for TS-mediated thymidine biosynthesis. Uridine, a ribonucleoside, indirectly activates TS by supplying a substrate for nucleotide biosynthesis. It is converted to uridine monophosphate (UMP), which can be further phosphorylated to deoxyuridine monophosphate (dUMP). TS then converts dUMP to deoxythymidine monophosphate (dTMP), facilitating thymidine biosynthesis and DNA replication when uridine is available in the cellular environment.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folic Acid, also known as vitamin B9, is an essential cofactor for TS. It indirectly activates TS by providing the one-carbon units necessary for thymidine biosynthesis. Folate is converted into active forms, such as tetrahydrofolate (THF), which serve as donors of methyl groups, enabling the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) by TS. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $36.00 $56.00 $148.00 $566.00 $1081.00 | ||
L-Methionine is an amino acid that indirectly activates TS by contributing to the one-carbon metabolism pathway. It serves as a methyl donor, participating in the methylation of homocysteine to form methionine. Methionine-derived methyl groups are subsequently used in the synthesis of THF, which is essential for TS-mediated conversion of dUMP to dTMP. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $39.00 $55.00 $204.00 $877.00 $3414.00 $9180.00 | 2 | |
Vitamin B12, also known as cobalamin, indirectly activates TS through its role in the one-carbon metabolism pathway. It acts as a cofactor for methionine synthase, which converts homocysteine to methionine. Methionine, in turn, contributes to the synthesis of THF, essential for TS-mediated thymidine biosynthesis. | ||||||
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $48.00 $72.00 $265.00 $449.00 $1724.00 $112.00 | 16 | |
Thymidine, a deoxyribonucleoside, is an indirect activator of TS by providing a direct substrate for the enzyme. TS catalyzes the conversion of deoxyuridine monophosphate (dUMP) into deoxythymidine monophosphate (dTMP) using thymidine as a precursor. | ||||||
L-Serine | 56-45-1 | sc-397670 sc-397670A sc-397670B sc-397670C sc-397670D | 1 g 100 g 1 kg 5 kg 10 kg | $20.00 $130.00 $535.00 $1200.00 $2000.00 | ||
Serine is an amino acid that indirectly activates TS through its involvement in one-carbon metabolism. Serine donates a methyl group for the synthesis of THF, a crucial cofactor for TS-mediated conversion of dUMP to dTMP. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+, a coenzyme involved in cellular metabolism, indirectly activates TS through its role in redox reactions. It contributes to the regeneration of dihydrofolate (DHF) to tetrahydrofolate (THF), a crucial cofactor for TS. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $102.00 | ||
Pyridoxal-5-phosphate, also known as vitamin B6, indirectly activates TS by participating in one-carbon metabolism. It facilitates the conversion of serine to glycine, a reaction that generates one-carbon units used in the synthesis of THF, a crucial cofactor for TS-mediated thymidine biosynthesis. | ||||||
Uridine | 58-96-8 | sc-296685 sc-296685A | 1 g 25 g | $60.00 $98.00 | 1 | |
Uridine, a ribonucleoside, indirectly activates TS by supplying a substrate for nucleotide biosynthesis. It is converted to uridine monophosphate (UMP), which can be further phosphorylated to deoxyuridine monophosphate (dUMP). | ||||||