Date published: 2026-6-10

1-800-457-3801

SCBT Portrait Logo
Seach Input

Trx Inhibitors

Trx inhibitors belong to a specific category of chemical compounds that are designed to interact with and modulate the function of thioredoxin (Trx), a key enzyme involved in cellular redox signaling and antioxidant defense mechanisms. Thioredoxin is responsible for regulating the redox state of various proteins by catalyzing the reduction of disulfide bonds, thus facilitating critical cellular processes such as DNA replication, protein folding, and cell proliferation. Inhibitors targeting Trx are meticulously developed to bind to specific sites on the enzyme's structure, altering its catalytic activity and disrupting its role in redox-mediated signaling pathways. The interaction between Trx inhibitors and the thioredoxin enzyme offers a unique approach to exploring the complex web of redox signaling within cells. By modulating Trx activity, these inhibitors provide a tool to decipher the intricate mechanisms underlying cellular responses to oxidative stress and their impact on various biological processes. The study of Trx inhibitors contributes to a deeper understanding of the role played by redox signaling in cellular homeostasis, stress response, and the maintenance of critical cellular functions. This chemical class enhances our knowledge of the regulatory networks that govern cellular adaptation to oxidative environments and shed light on the intricate crosstalk between redox signaling pathways and other cellular processes.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PX 12

141400-58-0sc-358518
sc-358518A
10 mg
50 mg
$133.00
$505.00
9
(1)

PX 12 is a distinctive acid halide known for its reactivity and ability to form stable intermediates during nucleophilic acyl substitution reactions. Its unique electronic configuration promotes rapid acylation of amines and alcohols, leading to diverse product formation. The compound exhibits strong dipole interactions, enhancing solubility in polar solvents. Furthermore, PX 12's steric properties influence reaction kinetics, allowing for selective transformations in complex organic syntheses.

PRIMA-1MET

5291-32-7sc-361295
sc-361295A
10 mg
25 mg
$153.00
$325.00
5
(1)

PRIMA-1MET is a notable acid halide characterized by its ability to engage in rapid electrophilic reactions, particularly with nucleophiles. Its unique structural features facilitate the formation of transient acyl-enzyme complexes, which can significantly alter reaction pathways. The compound's high reactivity is attributed to its electron-withdrawing halide, which stabilizes the transition state, thereby accelerating reaction rates. Additionally, PRIMA-1MET's solvation dynamics contribute to its behavior in various solvent systems, impacting its reactivity profile.

Auranofin

34031-32-8sc-202476
sc-202476A
sc-202476B
25 mg
100 mg
2 g
$153.00
$214.00
$4000.00
39
(2)

Auranofin inhibits TRX reductase activity, disrupting the TRX system's function in maintaining cellular redox balance and inhibiting cancer cell growth.

Cisplatin

15663-27-1sc-200896
sc-200896A
100 mg
500 mg
$138.00
$380.00
101
(4)

Cisplatin might indirectly impact TRX function by causing cellular oxidative stress and influencing redox signaling pathways.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Genistein might influence TRX function by modulating redox signaling and oxidative stress-related pathways.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin might affect TRX function by modulating redox signaling and antioxidant pathways, impacting cellular redox balance.