TRUB2 Activators

5-Azacytidine and S-Adenosylmethionine are involved in nucleic acid methylation processes, which are closely linked to RNA stability and processing. By altering these pathways, they can affect the pseudouridylation activity of TRUB2. Retinoic acid and EGCG can modify gene expression patterns, potentially leading to a cellular context that requires enhanced TRUB2 function for RNA stabilization. Forskolin and lithium chloride can impact signaling pathways that ultimately lead to changes in RNA processing activities, including those mediated by TRUB2.

Sodium butyrate and Trichostatin A, as histone deacetylase inhibitors, can cause widespread changes in gene expression that may include genes related to RNA modification and processing, thereby having an indirect impact on TRUB2 activity. Rapamycin, by inhibiting mTOR, affects protein synthesis and may also indirectly affect RNA processing, including TRUB2's role in pseudouridylation. Curcumin, through its effects on gene expression and RNA stability, can create a cellular environment that influences TRUB2 activity. Hydroxyurea and puromycin, although primarily targeting DNA synthesis and protein synthesis, respectively, have downstream effects on RNA processing pathways, which may necessitate altered TRUB2 activity for maintaining RNA stability and function.