Trk C Activators
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Demethylasterriquinone B1 | 78860-34-1 | sc-203025 | 5 mg | $510.00 | 2 | |
Demethylasterriquinone B1 acts as a selective modulator of the TrkC receptor, engaging in unique molecular interactions that promote receptor internalization. This compound alters the conformational landscape of TrkC, enhancing its affinity for specific downstream signaling partners. By influencing the phosphorylation state of critical tyrosine residues, it modulates the receptor's signaling pathways, ultimately affecting neuronal growth and differentiation processes. | ||||||
7,8-Dihydroxyflavone | 38183-03-8 | sc-278634 | 100 mg | $52.00 | 2 | |
7,8-Dihydroxyflavone, a natural flavonoid, acts as a direct Trk C agonist by binding to its extracellular domain. This binding triggers Trk C receptor activation, leading to autophosphorylation and the initiation of downstream signaling pathways. | ||||||
Tyrphostin AG 879 | 148741-30-4 | sc-3557 sc-3557A | 5 mg 25 mg | $83.00 $328.00 | 4 | |
AG879, a selective Trk inhibitor, indirectly activates Trk C by preventing its dephosphorylation. By inhibiting the activity of protein tyrosine phosphatases, AG879 maintains Trk C phosphorylation levels, enhancing its signaling activity. | ||||||
Entrectinib | 1108743-60-7 | sc-507438 | 5 mg | $180.00 | ||
A multi-kinase inhibitor that targets NTRK1, NTRK2, and NTRKIt has been investigated for various solid tumors harboring NTRK fusions. | ||||||
K-252a | 99533-80-9 | sc-200517 sc-200517B sc-200517A | 100 µg 500 µg 1 mg | $129.00 $214.00 $498.00 | 19 | |
K252a, a protein kinase inhibitor, indirectly activates Trk C by inhibiting kinases involved in its negative regulation. By suppressing these kinases, K252a promotes Trk C activation and downstream signaling cascades. | ||||||
GNF 5837 | 1033769-28-6 | sc-490003 | 5 mg | $81.00 | 1 | |
A small molecule inhibitor that selectively targets NTRK3 and exhibits potent anti-tumor activity in research models. | ||||||
GW-441756 | 504433-23-2 | sc-200683 sc-200683A | 10 mg 50 mg | $141.00 $565.00 | 3 | |
A selective inhibitor of the vascular endothelial growth factor receptor (VEGFR) that also targets NTRKIt has shown efficacy in research models for inhibiting NTRK3-mediated signaling. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine, a protein kinase inhibitor, indirectly activates Trk C by inhibiting kinases involved in its negative regulation. By suppressing these kinases, Staurosporine promotes Trk C activation and downstream signaling cascades. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I, a protein kinase C (PKC) inhibitor, indirectly activates Trk C by modulating PKC-dependent signaling. Inhibition of PKC prevents negative regulation of Trk C, promoting its activation and downstream signaling events. | ||||||
Tyrphostin A23 | 118409-57-7 | sc-3554 | 10 mg | $112.00 | 13 | |
Tyrphostin A23, a tyrosine kinase inhibitor, indirectly activates Trk C by inhibiting kinases involved in its negative regulation. By suppressing these kinases, AG18 promotes Trk C activation and downstream signaling cascades. | ||||||