Trim12c Inhibitors
Trim12c inhibitors represent a class of chemical compounds that specifically inhibit the activity of the TRIM12C protein, a member of the tripartite motif-containing (TRIM) protein family. TRIM proteins are characterized by their distinct structural motif, which includes a RING domain, one or two B-box domains, and a coiled-coil region. These domains facilitate their involvement in various cellular processes, particularly ubiquitination, which is essential for the regulation of protein degradation, signaling pathways, and other cellular mechanisms. TRIM12C is part of the subfamily of TRIM proteins known for its role in modulating protein-protein interactions and influencing post-translational modifications, particularly through ubiquitin ligase activity. Inhibitors targeting TRIM12C have garnered attention due to their ability to interfere with the protein's regulatory functions at the molecular level, leading to changes in intracellular signaling and protein homeostasis.
These inhibitors are chemically diverse, often containing structures that interact specifically with the RING domain or other key regions involved in TRIM12C's enzymatic function. The structural design of these inhibitors is guided by a deep understanding of protein-ligand interactions and the three-dimensional architecture of TRIM12C, ensuring high specificity and minimal interference with other TRIM proteins. The inhibition of TRIM12C can lead to the alteration of ubiquitin-mediated pathways, which can have far-reaching implications in cellular function, such as impacting protein stability, signal transduction, and autophagic processes. The development of these inhibitors is typically based on advanced chemical synthesis techniques, including structure-activity relationship (SAR) studies, high-throughput screening of small molecules, and computational modeling, all aimed at optimizing binding affinity and selectivity for TRIM12C.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Inhibits histone deacetylase, leading to hyperacetylation of histones, affecting the chromatin structure and potentially decreasing the accessibility of the DNA for proteins like tripartite motif-containing 12C, thereby inhibiting its function. | ||||||
Chetomin | 1403-36-7 | sc-202535 sc-202535A | 1 mg 5 mg | $186.00 $674.00 | 10 | |
Disrupts the structure of the hypoxia-inducible factor (HIF) transcription complex, which can be involved in the regulation of proteins including tripartite motif-containing 12C, leading to an inhibition of its activity in hypoxia-related pathways. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that prevents the degradation of ubiquitinated proteins, potentially leading to the accumulation of proteins that can inhibit the function of tripartite motif-containing 12C through competitive or allosteric interactions. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Specifically inhibits the proteasome's proteolytic activity, which could result in the accumulation of regulatory proteins that inhibit tripartite motif-containing 12C by steric hindrance or through post-translational modifications. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Inhibits mitochondrial ATP synthase, leading to reduced cellular ATP levels, which can inhibit the energy-dependent molecular interactions necessary for the function of tripartite motif-containing 12C. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Inhibits the nuclear export signal (NES)-mediated nuclear export by binding to exportin 1, potentially leading to the nuclear retention of proteins that inhibit the function of tripartite motif-containing 12C by affecting its subcellular localization. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts the Golgi apparatus structure and function, which can lead to a mislocalization and subsequent functional inhibition of proteins like tripartite motif-containing 12C that may rely on Golgi-mediated post-translational modifications. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Inhibits eukaryotic protein translation by interfering with the translocation step on the ribosome, potentially decreasing the levels of proteins that facilitate the function of tripartite motif-containing 12C, thus leading to its functional inhibition. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Inhibits the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation by modifying its subunit, which can alter the transcription of proteins including tripartite motif-containing 12C and inhibit its function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor that can inhibit a wide range of kinases, potentially affecting phosphorylation-dependent regulation of proteins like tripartite motif-containing 12C and inhibiting its function. | ||||||