Trav9d-1 Inhibitors
TRAV9n-3 inhibitors are a class of chemical compounds designed to target and inhibit the TRAV9n-3 gene segment, which encodes a variable region of the T-cell receptor alpha chain in mice. This receptor region plays a crucial role in recognizing antigens and initiating immune responses. By inhibiting TRAV9n-3, these compounds interfere with the formation of specific T-cell receptors, potentially affecting the ability of T cells to recognize and respond to antigens. This inhibition can lead to altered immune signaling and reduced activity in pathways dependent on T-cell receptor activation.
Chemically, TRAV9n-3 inhibitors are designed to block the binding or expression of this specific variable segment, preventing its proper integration into the T-cell receptor complex. Researchers focus on the structure of the variable region to ensure these inhibitors are selective for TRAV9n-3 without affecting other similar T-cell receptor regions. Studying these inhibitors helps illuminate the specific roles TRAV9n-3 plays in immune system regulation and antigen recognition, providing deeper insight into how individual T-cell receptor segments contribute to immune diversity and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin inhibits T cell receptor alpha variable 9D-1 expression by suppressing NF-κB activation, a transcription factor involved in the regulation of immune response genes. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine inhibits T cell receptor alpha variable 9D-1 expression by inhibiting STAT3 signaling pathway, a key regulator of T cell differentiation and cytokine production. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol inhibits T cell receptor alpha variable 9D-1 expression by inhibiting NF-κB activation and reducing the production of pro-inflammatory cytokines by T cells. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein inhibits T cell receptor alpha variable 9D-1 expression by blocking the activation of NF-κB pathway, thereby suppressing T cell-mediated immune responses. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin inhibits T cell receptor alpha variable 9D-1 expression by suppressing NF-κB activation and reducing T cell proliferation and cytokine production. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate inhibits T cell receptor alpha variable 9D-1 expression by blocking NF-κB activation and modulating signaling pathways involved in T cell activation. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol inhibits T cell receptor alpha variable 9D-1 expression by suppressing NF-κB activation and reducing T cell proliferation and production of pro-inflammatory cytokines. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits T cell receptor alpha variable 9D-1 expression by suppressing NF-κB activation and reducing T cell proliferation and production of pro-inflammatory cytokines. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide inhibits T cell receptor alpha variable 9D-1 expression by suppressing NF-κB activation and reducing T cell proliferation and production of pro-inflammatory cytokines. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
Emodin inhibits T cell receptor alpha variable 9D-1 expression by blocking NF-κB activation and reducing the production of pro-inflammatory cytokines by T cells. | ||||||