TRA-1-60 Activators
TRA-1-60 activators represent a diverse chemical class encompassing various compounds that play a pivotal role in influencing the expression of the TRA-1-60 protein. TRA-1-60, a cell surface marker associated with undifferentiated human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), serves as an indicator of the pluripotent state of these cells. The activators within this chemical class operate through intricate signaling pathways, impacting the molecular events that regulate TRA-1-60 expression and, consequently, the maintenance of pluripotency in stem cells.
Several compounds classified as TRA-1-60 activators include signaling molecules crucial for embryonic development and stem cell fate determination. Retinoic acid, for instance, participates in stem cell differentiation, influencing the transition from pluripotency to a differentiated state and modulating TRA-1-60 levels. Growth factors such as bone morphogenetic protein 4 (BMP-4) and fibroblast growth factor 2 (FGF-2) contribute to TRA-1-60 expression by activating downstream pathways involved in stem cell pluripotency and differentiation. Additionally, chemicals like 5-azacytidine and hexachlorophene impact TRA-1-60 through epigenetic modifications and cellular responses, respectively. Together, these activators underscore the complexity of the regulatory networks governing TRA-1-60 expression, shedding light on the intricate processes that dictate the undifferentiated state of embryonic and induced pluripotent stem cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid induces TRA-1-60 expression. It plays a role in stem cell differentiation, and its signaling pathways influence the transition from a pluripotent to a differentiated state, thereby modulating the levels of TRA-1-60 on the cell surface. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine influences TRA-1-60 expression. As a demethylating agent, it can alter the epigenetic landscape of stem cells, affecting their differentiation. The changes in epigenetic regulation contribute to the modulation of TRA-1-60 levels during cellular differentiation processes. | ||||||
β-Mercaptoethanol | 60-24-2 | sc-202966A sc-202966 | 100 ml 250 ml | $90.00 $120.00 | 10 | |
2-Mercaptoethanol influences TRA-1-60 expression. As a reducing agent, it modulates cellular redox status, impacting stem cell differentiation. The alterations in redox signaling pathways contribute to the regulation of TRA-1-60 levels during the processes of stem cell fate determination. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid induces TRA-1-60 expression. It plays a role in regulating pluripotency and differentiation of stem cells. The impact on intracellular signaling pathways, including epigenetic modifications, contributes to the modulation of TRA-1-60 levels during stem cell differentiation. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide influences TRA-1-60 expression. As a protein synthesis inhibitor, it affects the cellular proteome and can impact stem cell differentiation. The changes in protein expression patterns contribute to the regulation of TRA-1-60 levels during the processes of cellular differentiation. | ||||||
Hexachlorophene | 70-30-4 | sc-211587 | 1 g | $247.00 | 1 | |
Hexachlorophene induces TRA-1-60 expression. As a disinfectant, it can modulate cellular responses, impacting stem cell fate determination. The mechanisms involved, possibly through cell surface interactions, contribute to the regulation of TRA-1-60 levels during cellular differentiation. | ||||||