TP53INP1 Activators
TP53INP1 activators, in the current scientific context, are primarily chemicals that indirectly influence the expression or activity of TP53INP1 through the modulation of p53 or related stress response pathways. TP53INP1 is a stress-induced protein that enhances the tumor suppressor function of p53, playing a crucial role in cell cycle arrest and apoptosis. The activators listed include a variety of compounds that either directly activate p53, like Nutlin-3a, RITA, and Prima-1MET, or induce cellular stress leading to p53 activation, such as Piperlongumine, Camptothecin, and Doxorubicin. Nutlin-3a specifically antagonizes MDM2, a negative regulator of p53, leading to the stabilization and activation of p53. RITA and Prima-1MET work by reactivating p53, with Prima-1MET targeting mutant forms of p53. Compounds like Tenovin-6 inhibit sirtuins, which in turn leads to p53 acetylation and activation.
Agents such as 5-Fluorouracil and Doxorubicin exert their effects through DNA damage, which is a potent activator of the p53 pathway. This DNA damage response is a critical pathway through which TP53INP1 can be upregulated, as TP53INP1 expression is closely linked to p53 activation.Natural compounds like Quercetin, Resveratrol, Sulforaphane, and Curcumin also play a role in this context. These compounds are known for their various health benefits and have been shown to influence p53 activity in certain cell types. Their ability to modulate the p53 pathway suggests an indirect effect on TP53INP1 expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(–)-Nutlin-3 | 675576-98-4 | sc-222086 sc-222086A | 1 mg 5 mg | $122.00 $219.00 | 2 | |
Nutlin-3a is a MDM2 antagonist that activates p53 by preventing its interaction with MDM2. This activation of p53 can lead to increased expression of TP53INP1, as TP53INP1 is a p53-responsive gene. | ||||||
p53 Activator III, RITA | 213261-59-7 | sc-202753 sc-202753A sc-202753B sc-202753C | 1 mg 10 mg 100 mg 500 mg | $112.00 $273.00 $1564.00 $5205.00 | 9 | |
RITA is known to reactivate p53, leading to apoptosis in p53 wild-type tumor cells. By activating p53, RITA may indirectly upregulate TP53INP1 expression. | ||||||
PRIMA-1MET | 5291-32-7 | sc-361295 sc-361295A | 10 mg 25 mg | $153.00 $325.00 | 5 | |
Prima-1MET reactivates mutant p53 and restores its wild-type conformation. This reactivation can enhance the expression of p53 target genes, including TP53INP1. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Tenovin-6 acts as a SIRT1 and SIRT2 inhibitor, leading to p53 acetylation and activation. This activation might increase TP53INP1 expression as part of the p53 response. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine increases ROS levels, leading to DNA damage and subsequent activation of the p53 pathway. This could indirectly lead to the upregulation of TP53INP1. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that induces DNA damage, potentially enhancing p53 activity and subsequently TP53INP1 expression. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-FU is a chemotherapeutic agent causing DNA damage and eliciting a p53 response, which may include the upregulation of TP53INP1. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin, an anthracycline antibiotic, induces DNA damage and activates p53, potentially enhancing TP53INP1 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, has been shown to activate the p53 pathway in certain cell types, which may lead to increased expression of TP53INP1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can activate the p53 pathway and has been associated with inducing apoptosis in cancer cells. This activation may indirectly upregulate TP53INP1. | ||||||