Date published: 2025-10-15

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Topo II alpha Inhibitors

Santa Cruz Biotechnology now offers a broad range of Topo II alpha Inhibitors for use in various applications. Topo II alpha inhibitors are a vital category of compounds in the field of molecular biology and biochemistry, primarily used to study the intricate mechanisms of DNA replication, transcription, and repair. These inhibitors target the enzyme topoisomerase II alpha, which plays a critical role in managing DNA topology during cell division. By inhibiting this enzyme, researchers can induce DNA damage, making these compounds invaluable tools for understanding the cellular responses to DNA stress, such as DNA repair pathways and cell cycle checkpoints. In addition to their role in basic research, Topo II alpha inhibitors are utilized in biotechnology for the development of novel assays and the screening of potential new chemical entities that modulate DNA processes. Their use extends to genetic studies, where they help explain the function of topoisomerases in genome stability and integrity. With the ability to selectively inhibit topoisomerase II alpha, these compounds offer a powerful means to dissect the molecular underpinnings of chromosomal dynamics. View detailed information on our available Topo II alpha Inhibitors by clicking on the product name.

Items 11 to 12 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Alternariol monomethyl ether

26894-49-5sc-206070
sc-206070A
1 mg
5 mg
$260.00
$610.00
1
(0)

Alternariol monomethyl ether acts as a topoisomerase II alpha inhibitor by engaging with the enzyme's active site, inducing conformational changes that hinder its catalytic function. Its structural features promote specific hydrogen bonding and hydrophobic interactions, enhancing binding stability. The compound's unique electronic properties influence the reaction kinetics, leading to a modulation of DNA topology and impacting the overall cellular processes involving DNA replication and repair.

Gatifloxacin-d4

sc-218565
1 mg
$360.00
(0)

Gatifloxacin-d4 interacts with topoisomerase II alpha through a unique mechanism that stabilizes the enzyme's closed conformation, effectively obstructing its activity. The compound's isotopic labeling enhances its detection in biochemical assays, allowing for precise tracking of molecular interactions. Its distinct steric and electronic characteristics facilitate selective binding, influencing the enzyme's dynamics and altering the equilibrium of DNA supercoiling, thereby affecting nucleic acid metabolism.