Date published: 2025-12-14

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TopBP1 Antibodies

Santa Cruz Biotechnology features a diverse variety of TopBP1 monoclonal antibodies for investigating cellular processes. TopBP1 monoclonal antibodies are suitable for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). TopBP1, or Topoisomerase II-Binding Protein 1, functions as a crucial regulator of DNA damage response and repair mechanisms. TopBP1 maintains genomic stability by facilitating the activation of ATR, a key protein in the DNA damage checkpoint pathway. Understanding TopBP1 function is essential for cancer biology research and developing targeted treatments. TopBP1 research continues to reveal new insights about DNA damage response pathways and their regulation. Current studies focus on how TopBP1 coordinates with other proteins to maintain genome integrity. Investigating TopBP1's role in cancer development may lead to breakthrough therapeutic strategies. Santa Cruz Biotechnology monoclonal antibodies enable researchers worldwide to advance scientific understanding of DNA damage response mechanisms and cancer biology.

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TopBP1 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

TopBP1 Antibody (B-7)

sc-271043mouse IgG1 κ1382-1417 (h)WB, IP, IF, ELISAh
23
(9)

TopBP1 Antibody (33)

sc-136106mouse IgG1204-416 (h)WB, IP, IFh

new

(2)

TopBP1 CRISPR Knockout, HDR and Double Nickase Plasmids

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TopBP1 CRISPR/Cas9 KO Plasmid (h)

sc-402703hGene KnockoutGFP0
(0)

TopBP1 HDR Plasmid (h)

sc-402703-HDRhHomology Directed RepairPuromycin0
(0)

TopBP1 Double Nickase Plasmid (h)

sc-402703-NIChGene KnockoutPuromycin0
(0)

TopBP1 Double Nickase Plasmid (h2)

sc-402703-NIC-2hGene KnockoutPuromycin0
(0)

TopBP1 CRISPR/Cas9 KO Plasmid (m)

sc-433472mGene KnockoutGFP0
(0)

TopBP1 HDR Plasmid (m)

sc-433472-HDRmHomology Directed RepairPuromycin0
(0)

TopBP1 Double Nickase Plasmid (m)

sc-433472-NICmGene KnockoutPuromycin0
(0)

TopBP1 Double Nickase Plasmid (m2)

sc-433472-NIC-2mGene KnockoutPuromycin0
(0)

TopBP1 CRISPR Activation Products

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TopBP1 CRISPR Activation Plasmid (h)

sc-402703-ACThGene ActivationPuro, Blast, Hygro0
(0)

TopBP1 CRISPR Activation Plasmid (h2)

sc-402703-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

TopBP1 Lentiviral Activation Particles (h)

sc-402703-LAChGene ActivationPuro, Blast, Hygro0
(0)

TopBP1 Lentiviral Activation Particles (h2)

sc-402703-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

TopBP1 CRISPR Activation Plasmid (m)

sc-433472-ACTmGene ActivationPuro, Blast, Hygro0
(0)

TopBP1 CRISPR Activation Plasmid (m2)

sc-433472-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

TopBP1 Lentiviral Activation Particles (m)

sc-433472-LACmGene ActivationPuro, Blast, Hygro0
(0)

TopBP1 Lentiviral Activation Particles (m2)

sc-433472-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

TopBP1 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

TopBP1 siRNA (h)

sc-41068hGene SilencingN/A
4
(0)

TopBP1 shRNA Plasmid (h)

sc-41068-SHhGene SilencingPuromycin
4
(0)

TopBP1 shRNA (h) Lentiviral Particles

sc-41068-VhGene SilencingPuromycin
4
(0)

TopBP1 siRNA (m)

sc-44393mGene SilencingN/A0
(0)

TopBP1 shRNA Plasmid (m)

sc-44393-SHmGene SilencingPuromycin0
(0)

TopBP1 shRNA (m) Lentiviral Particles

sc-44393-VmGene SilencingPuromycin0
(0)