TNF-IP 8L2 Inhibitors
Chemical inhibitors of TNF-IP 8L2 can modulate various cellular processes by interfering with the protein's role in apoptosis, necroptosis, cytoskeletal remodeling, and cell survival pathways. Z-VAD-FMK is a broad-spectrum caspase inhibitor that can prevent apoptosis by blocking the caspase enzymes that TNF-IP 8L2 may regulate. Similarly, Necrostatin-1, by inhibiting RIPK1, can disrupt necroptosis, a programmed form of necrosis linked with TNF-IP 8L2. In the context of cellular architecture, NSC 23766 disrupts the interaction of Rac1 with its GEFs, potentially altering the cytoskeletal organization and cellular remodeling processes associated with TNF-IP 8L2's function. LY294002 and Wortmannin, both inhibitors of PI3K, can obstruct the PI3K signaling pathway, thereby affecting the role of TNF-IP 8L2 in cell proliferation and survival.
Further manipulation of signaling pathways relevant to TNF-IP 8L2's functional role includes the use of PD98059 and U0126, which are selective inhibitors of the MEK1/2 enzymes in the MAPK/ERK pathway, a pathway known to be involved in cell proliferation and survival. Inhibiting this pathway can alter the function of TNF-IP 8L2 in these processes. SB203580 and SP600125 target the p38 MAPK and JNK signaling pathways, respectively, both of which are involved in cellular stress responses. By inhibiting these kinases, the ability of TNF-IP 8L2 to influence stress response pathways is affected. BAY 11-7082 interferes with the NF-κB signaling pathway, which is central to inflammation and cell survival, and thus can alter TNF-IP 8L2's role in these processes. Lastly, Y-27632 inhibits ROCK, potentially affecting TNF-IP 8L2's involvement in actin cytoskeleton organization, while MG-132's inhibition of proteasome activity can prevent the degradation of proteins that interact with or regulate TNF-IP 8L2.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Z-VAD-FMK | 187389-52-2 | sc-3067 | 500 µg | $75.00 | 256 | |
This is a pan-caspase inhibitor that can inhibit apoptosis. Given that TNF-IP 8L2 can be involved in apoptotic signaling, the inhibition of caspases may prevent the apoptotic events that TNF-IP 8L2 may be regulating, thus functionally inhibiting its role in apoptosis. | ||||||
Necrostatin-1 | 4311-88-0 | sc-200142 sc-200142A | 20 mg 100 mg | $94.00 $343.00 | 97 | |
Inhibitor of RIPK1, a kinase implicated in necroptosis. TNF-IP 8L2 has been linked to cell death pathways including necroptosis. By inhibiting RIPK1, Necrostatin-1 can inhibit necroptosis, a process in which TNF-IP 8L2 may be involved. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
Selective inhibitor of Rac1 GTPase interaction with its specific guanine nucleotide exchange factors (GEFs). Since TNF-IP 8L2 is associated with cytoskeletal remodeling, the inhibition of Rac1 can disrupt this process and thereby inhibit the functional role of TNF-IP 8L2 in actin cytoskeleton organization. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A potent inhibitor of phosphoinositide 3-kinases (PI3Ks), which are upstream of many cellular processes including cell survival and proliferation. Since TNF-IP 8L2 is involved in cell survival pathways, inhibiting PI3K can disrupt signals that TNF-IP 8L2 relies on to exert its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor that blocks the MAPK/ERK pathway, which is involved in cell proliferation and survival. By inhibiting this pathway, PD98059 can prevent the activation of downstream targets of TNF-IP 8L2, functionally inhibiting its role in these processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A well-known inhibitor of p38 MAPK, a protein involved in stress response pathways. TNF-IP 8L2, which may play a role in these pathways, will be functionally inhibited if the p38 MAPK signaling is blocked. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), which is involved in stress responses and apoptosis. TNF-IP 8L2's function related to these pathways can be inhibited by the action of SP600125, which blocks JNK signaling. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
An NF-κB pathway inhibitor that can prevent the activation of NF-κB, a transcription factor that TNF-IP 8L2 may regulate or be regulated by. By inhibiting NF-κB, BAY 11-7082 can inhibit the functional role of TNF-IP 8L2 in inflammatory signaling pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
A selective inhibitor of MEK1/2, enzymes upstream of ERK in the MAPK pathway. Inhibition of this pathway by U0126 can result in the functional inhibition of TNF-IP 8L2 as it may rely on the MAPK pathway for its role in cell survival and proliferation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
A potent inhibitor of PI3K, which is critical for many aspects of cell growth and survival. TNF-IP 8L2, potentially functioning in these pathways, can be functionally inhibited by Wortmannin's action on PI3K. | ||||||