TMEM155 Inhibitors
TMEM155 inhibitors constitute a class of chemical compounds that specifically target and inhibit the function of the protein encoded by the TMEM155 gene. TMEM155, short for transmembrane protein 155, is embedded within the cellular membrane and is implicated in various cellular functions. The inhibitors designed to bind to this protein typically work by blocking its active site or altering its conformation in such a way that its normal function is disrupted. The precise mechanism of action of these inhibitors is determined by the unique structure of the TMEM155 protein, which usually involves a complex interplay between the inhibitor molecule and protein domains that are crucial for TMEM155's activity. The design of TMEM155 inhibitors is a sophisticated process that often requires a detailed understanding of the protein's structure, including the arrangement of its transmembrane domains, to predict and enhance binding affinity and specificity.
The development and characterization of TMEM155 inhibitors involve an array of chemical techniques. Structure-activity relationship (SAR) studies are commonly employed to refine the efficacy of these inhibitors by systematically modifying their chemical structure and evaluating the consequent changes in function. Advanced analytical methods such as X-ray crystallography or cryo-electron microscopy may be used to visualize the interaction at a molecular level, providing insights into the binding modes and identifying key interactions between the inhibitor and the protein. Computational approaches like molecular docking and dynamic simulations also play an integral role in predicting how these inhibitors might interact with TMEM155, guiding the design of molecules with improved properties. The chemical synthesis of TMEM155 inhibitors is another critical aspect, often requiring multi-step synthetic routes to produce the desired compounds with high purity and yield. The inhibitors are usually characterized by a range of physicochemical properties, including solubility, stability, and molecular weight, which are essential for their specific inhibitory function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that reduces cellular proliferation and growth. Given that TMEM155 is implicated in processes related to cell growth, rapamycin could lead to the functional inhibition of TMEM155 by decreasing the overall cellular capacity for processes in which TMEM155 is involved. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that impedes the PI3K/AKT/mTOR signaling pathway. As TMEM155 may be linked to this pathway, inhibition of PI3K could indirectly decrease TMEM155's functional activity by disrupting downstream signals that TMEM155 may depend on. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor, similar to LY294002, that would inhibit downstream signaling potentially involving TMEM155, thereby decreasing its functional activity through disruption of the PI3K/AKT/mTOR pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor, which would prevent the activation of the ERK/MAPK pathway. As the ERK/MAPK pathway is involved in cell proliferation and survival, inhibition here may indirectly affect TMEM155's activity if TMEM155 is part of these cellular processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, and by inhibiting p38 MAPK, it may disrupt cellular stress responses, potentially influencing TMEM155's functional activity if TMEM155 is implicated in these responses. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor which could impede the JNK signaling pathway, often involved in apoptosis and cell survival. If TMEM155 is related to these processes, its activity could be indirectly inhibited. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts protein transport by inhibiting ADP-ribosylation factor, which could indirectly affect TMEM155 if it relies on intracellular trafficking for its function. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an immunosuppressant that inhibits calcineurin, thereby preventing the activation of T-cells. If TMEM155 is involved in immune cell function, its activity could be indirectly suppressed by this compound. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose is a glucose analog that inhibits glycolysis. If TMEM155 is involved in metabolic processes, the inhibition of glycolysis could decrease TMEM155's activity by limiting energy supply. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, impairing the ERK/MAPK signaling pathway, potentially affecting TMEM155 if it is associated with cellular proliferation and differentiation pathways that are regulated by this pathway. | ||||||