Brefeldin A CAS: 20350-15-6
MF: C16H24O4
MW: 280.36
A fungal metabolite exhibiting a wide range of antibiotic activities and activator of caspase-3.

Brefeldin A (CAS 20350-15-6)

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同义词: γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin
应用; A fungal metabolite exhibiting a wide range of antibiotic activities and activator of caspase-3
CAS号码: 20350-15-6
纯度: ≥98%
分子量: 280.36
分子式: C16H24O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 参考分析证明 大量特定数据 (包括水 含量).
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Brefeldin A is a fungal metabolite that disrupts the structure and function of the Golgi apparatus. The compound induces the Golgi proteins to redistribute into the ER and blocks the secretion from the Golgi apparatus. Studies show that it blocks the GTP-dependent interaction of ARF with the Golgi membrane, thus inhibiting the assembly of coatomer onto the membrane. Research shows that Brefeldin A can induce apoptosis in Neuroendocrine tumor cells by activating caspase-3, and inhibits cell growth by targeting the cell cycle in prostate cancer cells. Brefeldin A is an inhibitor of ARF.


参考文献

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8. Larsson, D.E., et al. 2010. Anticancer Res. 30: 149-156. PMID: 20150630
9. Rajamahanty, S., et al. 2010. J. Biomed. Sci. 17: 5. PMID: 20102617

物理状态 :
Solid
来源于 :
Eupenicillum sp. UN88
溶解度 :
Soluble in water (Partly miscible), methanol (10 mg/mL), ethanol (5 mg/mL), DMSO (20 mg/mL), acetone, and ethyl acetate (1 mg/mL).
保存 :
Store at -20° C
熔点 :
200° C
沸点 :
~492.7° C at 760 mmHg (Predicted)
密度 :
~1.1 g/cm3 (Predicted)
折射率 :
n20D 1.51
光学活性 :
α20/D 96°±2° in methanol; α20/D 93°, c = 2 in methanol
IC50 :
B-cell specific antigen receptor-induced NF-kB activation: IC50 = 420 nM (HEK-293T cell line)
pK值 :
pKa: 12.92
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
GY8410000
PubChem CID :
5287620
默克索引 :
14: 1369
MDL 号码 :
MFCD00083258
EC号码 :
247-104-4
Beilstein 注册 :
25191

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