TMEM149 Inhibitors
Chemical inhibitors of TMEM149 can affect the activity of this protein through various mechanisms by targeting different kinases and enzymes that are involved in its regulation. Staurosporine, a broad-spectrum kinase inhibitor, can lead to reduced activity of TMEM149 by hindering the phosphorylation events that are essential for its function. Bisindolylmaleimide I, by selectively inhibiting protein kinase C (PKC), can decrease TMEM149 activity, suggesting that PKC-mediated phosphorylation is significant for TMEM149's role. Similarly, Gö 6983 and LY333531, which inhibit PKC isoforms and PKC beta isoforms respectively, can also suppress TMEM149 activity by blocking the PKC-dependent signaling pathways that TMEM149 relies on. Inhibition of these pathways likely prevents the activation or regulatory phosphorylation of TMEM149.
Furthermore, Wortmannin and LY294002 specifically target phosphoinositide 3-kinases (PI3K), which are upstream regulators in many signaling pathways, and by disrupting PI3K activity, these inhibitors can decrease TMEM149 function. This implies that TMEM149 may depend on PI3K signaling for its activity. Other inhibitors such as SP600125 and AG490 target the JNK and JAK/STAT signaling pathways, respectively, which can also lead to a decrease in TMEM149 activity. This effect indicates a possible regulatory role for these pathways in TMEM149's function. Additionally, U0126 and PD98059, which both inhibit MEK1/2 in the MAPK pathway, can reduce the activity of TMEM149, suggesting that MEK-mediated pathways contribute to the regulatory processes of TMEM149. Lastly, SB203580 and PP2, which inhibit p38 MAP kinase and Src family tyrosine kinases respectively, can also cause a decrease in TMEM149 activity, pointing to the involvement of these kinases in the functional modulation of TMEM149.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine inhibits a broad spectrum of protein kinases which could be upstream regulators or part of the signaling cascade necessary for TMEM149 function. By inhibiting these kinases, Staurosporine may lead to a reduction in TMEM149 activity through the suppression of necessary phosphorylation events. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I functions as an inhibitor of protein kinase C (PKC). Since PKC can be involved in the signaling pathways that regulate various transmembrane proteins, inhibiting PKC can decrease the activity of TMEM149 by preventing necessary phosphorylation processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of phosphoinositide 3-kinases (PI3K). By blocking PI3K, it can disrupt downstream signaling pathways that are essential for TMEM149's functional activity, leading to a decrease in its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor, which by the same mechanism as Wortmannin, can decrease the activity of TMEM149 by disrupting the PI3K-dependent signaling processes that TMEM149 requires for its function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits c-Jun N-terminal kinase (JNK). JNK is part of the MAPK signaling pathway, which may be involved in the regulation of TMEM149. Inhibition of JNK could lead to a decrease in TMEM149 activity by blocking the phosphorylation signaling that it may depend on. | ||||||
AG-490 | 133550-30-8 | sc-202046C sc-202046A sc-202046B sc-202046 | 5 mg 50 mg 25 mg 10 mg | $82.00 $323.00 $219.00 $85.00 | 35 | |
AG490 inhibits the JAK/STAT signaling pathway. This pathway can be involved in the regulation of transmembrane proteins. Thus, by inhibiting this pathway, AG490 can lead to functional inhibition of TMEM149 through the suppression of necessary activation signals. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 selectively inhibits MEK1/2, which are kinases within the MAPK pathway. If TMEM149 is regulated through the MAPK pathway, the inhibition of MEK1/2 can lead to a decrease in TMEM149 activity by preventing its activation through this pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor similar to U0126, and thereby can decrease TMEM149 activity by blocking the MAPK pathway and the subsequent phosphorylation that TMEM149 may require for its function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 specifically inhibits p38 MAP kinase, another kinase in the MAPK pathway. By inhibiting p38 MAP kinase, SB203580 can reduce TMEM149 activity if p38 MAP kinase is involved in its activation or regulation. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. These kinases can regulate transmembrane proteins, and thus, by inhibiting them, PP2 can lead to a decrease in TMEM149 activity by preventing activation signals that are dependent on Src kinase activity. | ||||||