TMEM111 Activators
The chemical class termed TMEM111/EMC3 Activators includes a variety of compounds that indirectly influence the function of TMEM111/EMC3 within the endoplasmic reticulum. These activators work not by directly interacting with TMEM111/EMC3, but by altering the cellular environment, particularly the conditions within the ER that are crucial for TMEM111/EMC3's role in protein folding and membrane protein complex assembly.
Chemicals like Tunicamycin, Thapsigargin, and Brefeldin A induce ER stress by different mechanisms - inhibiting N-linked glycosylation, disrupting calcium homeostasis, and impairing ER-to-Golgi transport, respectively. These stressors can potentially enhance the functional demand on TMEM111/EMC3, as it plays a role in managing protein folding and assembly under stress conditions. Dithiothreitol (DTT) and Beta-Mercaptoethanol, as reducing agents, directly impact the protein folding environment within the ER, potentially influencing TMEM111/EMC3's activity in assisting proper protein folding and maintenance.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts ER-to-Golgi transport, causing ER stress, which could influence TMEM111/EMC3 activity. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Modifies calcium levels in the ER, affecting ER functions and potentially TMEM111/EMC3 activity. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Acts as a chemical chaperone, potentially affecting TMEM111/EMC3's role in protein folding. | ||||||
β-Mercaptoethanol | 60-24-2 | sc-202966A sc-202966 | 100 ml 250 ml | $90.00 $120.00 | 10 | |
Reducing agent that can cause protein misfolding in the ER, potentially impacting TMEM111/EMC3. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
An HSP90 inhibitor, which can cause accumulation of unfolded proteins in ER, influencing TMEM111/EMC3. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Modifies metal ion balance in ER, potentially influencing protein folding and TMEM111/EMC3 function. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Another HSP90 inhibitor, potentially affecting protein folding in ER and TMEM111/EMC3 activity. | ||||||
Nelfinavir | 159989-64-7 | sc-507314 | 10 mg | $168.00 | ||
An ER stress inducer, can modulate ER function and possibly affect TMEM111/EMC3. | ||||||