Sodium phenylbutyrate CAS: 1716-12-7
MF: C10H11O2•Na
MW: 186.18

Sodium phenylbutyrate (CAS 1716-12-7)

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Nombres Alternativos: Sodium phenylbutyrate is also known as Sodium 4-Phenylbutyrate.
Solicitud: Sodium phenylbutyrate is an HDAC inhibitor and caspase activator shown to rescue the trafficking of misfolded proteins.
Número de CAS: 1716-12-7
Pureza: ≥98%
Peso Molecular: 186.18
Fórmula Molecular: C10H11O2•Na
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).

Sodium phenylbutyrate, an HDAC (histone deacetylase) inhibitor, has been shown to cause cellular differentiation, growth arrest, and apoptosis in certain cells. Sodium phenylbutyrate has been reported to cause cell growth arrest at the G1 phase and induce apoptosis through activation of JNK. Studies suggest that Sodium Phenylbutyrate also acts as a chemical chaperone by causing a reduction of the load of mutant and mislocated proteins retained in the endoplasmic reticulum (ER). Other experiments have noted that Sodium Phenylbutyrate demonstrates neuroprotective capabilities by attenuating infarction volume, apoptosis, hemispheric swelling and improving neurological status in a murine model of hypoxia-ischemia. Moreover, Sodium phenylbutyrate has been shown to suppress ER-mediated apoptosis by initiating factor 2α phosphorylation, caspase-12 activation, and CCAAT/enhancer-binding protein homologous protein induction.


References

1. Appelskog, I.B., et al. 2004. Int. J. Oncol. 24: 1419-1425. PMID: 15138583

2. Zhang, X., et al. 2004. J. Cell. Biochem. 93: 819-829. PMID: 15389886

3. Qi, X., et al. 2004. Mol. Pharmacol. 66: 899-908. PMID: 15226415

4. Gardian, G., et al. 2005. J. Biol. Chem. 280: 556-563. PMID: 15494404

Uso :
Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (25 mM), water (25 mg/ml), and ethanol.
ALMACENAMIENTO :
Store at room temperature
Punto de Fusión :
214-216° C
Datos Ki :
Inhibition of HDAC: Ki= 6.34 µM (human Hela cells nuclear extracts)
Valores de pK :
pKa: 4.76 (Predicted)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
RTECS :
CY9057220
PubChem CID :
5258
Número MDL :
MFCD00800247
SMILES :
C1=CC=C(C=C1)CCCC(=O)[O-].[Na+]

Descargar SDS (MSDS)

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PMID: # 31320609  Qiu, Y. et al. 2019. Cell Death Dis. 10: 547.

PMID: # 30224704  Ingles, J.|Simpson, A.|Kyathanahalli, C.|Anamthathmakula, P.|Hassan, S.|Jeyasuria, P.|Condon, JC.| et al. 2018. Cell Death Dis. 9: 933.

PMID: # 29080681  Yang, F.|Yang, L.|Wataya-Kaneda, M.|Yoshimura, T.|Tanemura, A.|Katayama, I.| et al. 2018. J. Invest. Dermatol. 138: 669-678.

PMID: # 30100737  Chen, J. et al. 2018. Onco Targets Ther. 11: 4315-4325.

PMID: # 28444766  Zhu, G.|Tao, L.|Wang, R.|Xue, Y.|Wang, X.|Yang, S.|Sun, X.|Gao, G.|Mao, Z.|Yang, Q.| et al. 2017. J. Neurochem. 142: 272-285.

PMID: # 27341688  Sanda, GM.|Deleanu, M.|Toma, L.|Stancu, CS.|Simionescu, M.|Sima, AV.| et al. 2017. J. Cell. Biochem. 118: 661-669.

PMID: # 28316566  Huang, L.|Xue, Y.|Feng, D.|Yang, R.|Nie, T.|Zhu, G.|Tao, K.|Gao, G.|Yang, Q.| et al. 2017. Front Cell Neurosci. 11: 52.

PMID: # 29235576  Eigner, K.|Filik, Y.|Mark, F.|Schütz, B.|Klambauer, G.|Moriggl, R.|Hengstschläger, M.|Stangl, H.|Mikula, M.|Röhrl, C.| et al. 2017. Sci Rep. 7: 17498.

PMID: # 27206739  Toma, L. et al. 2016. Mol. Cell. Biochem. 417: 169-79.

PMID: # 27337297  Periyasamy, P.|Guo, ML.|Buch, S.| et al. 2016. Autophagy. 12: 1310-29.

Citaciones 1 a 10 de un total de 26
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