TMEM101 Inhibitors
Ouabain-d3 targets the Na⁺/K⁺-ATPase, a pivotal enzyme in maintaining the electrochemical gradient across the cell membrane, which is a cornerstone of cellular signaling and homeostasis, potentially altering the environment in which TMEM101 operates. Bafilomycin A1, a potent V-ATPase inhibitor, disrupts vesicular acidification, a critical determinant of membrane protein sorting and trafficking, thus indirectly bearing upon TMEM101's cellular itinerary. Kinase activity is integral to cellular signaling, and inhibitors like Genistein and Gö 6976, which target tyrosine kinases and protein kinase C, respectively, can modulate phosphorylation landscapes, affecting signaling cascades linked to TMEM101. The inhibition of endocytosis by Dynasore and Chlorpromazine, through their actions on dynamin and clathrin, respectively, can influence the membrane cycling of TMEM101, altering its availability and function on the cell surface.
Calcium is a universal signaling molecule, and agents such as 2-APB and Thapsigargin that affect calcium homeostasis can have broad effects on cellular processes. By modulating IP3 receptors, TRP channels, and the sarcoplasmic/endoplasmic reticulum Ca²⁺ ATPase, these chemicals can change the intracellular calcium landscape, with potential repercussions for TMEM101-associated signaling. Monensin and FCM Lysing solution (1x), through their effects on ion exchange and vesicular pH, respectively, can lead to disturbances in pH homeostasis, which is known to influence the behavior of transmembrane proteins. The process of glycosylation is crucial for the proper folding and function of membrane proteins. Tunicamycin's inhibition of N-linked glycosylation can thus compromise the structural integrity and positioning of TMEM101 within the cell. Similarly, the cytoskeleton is fundamental for cellular shape and the trafficking of vesicles and proteins. ML-9, by inhibiting myosin light-chain kinase, can affect cytoskeletal dynamics, potentially altering the transport and localization of TMEM101.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
Inhibits Na⁺/K⁺-ATPase, could alter ionic gradients and cell signaling, indirectly affecting TMEM101-associated processes. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Specific inhibitor of V-ATPase, can disrupt vesicular acidification and trafficking, which may indirectly influence TMEM101 function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Tyrosine kinase inhibitor, can alter signaling pathways and potentially affect the regulation of TMEM101. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Inhibitor of dynamin, can disrupt endocytosis and vesicle trafficking, processes that might be connected to TMEM101 function. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
Inhibits IP3 receptors and TRP channels, can affect calcium signaling, potentially altering TMEM101 function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Ionophore that disrupts Na⁺/H⁺ exchange, can affect pH and ion homeostasis, which might indirectly impact TMEM101. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Inhibitor of N-linked glycosylation, can impact protein folding and trafficking, potentially affecting TMEM101. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Inhibitor of the sarcoplasmic/endoplasmic reticulum Ca²⁺ ATPase (SERCA), can disrupt calcium homeostasis, possibly affecting TMEM101. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Blocks dopamine receptors, can also inhibit clathrin-mediated endocytosis, potentially affecting TMEM101-associated trafficking. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
Inhibits myosin light-chain kinase, can affect cytoskeleton dynamics, potentially altering TMEM101's cellular context. | ||||||