TK2 Inhibitors
TK2 inhibitors belong to a distinct chemical class characterized by their specific mode of action and interaction with cellular components. These compounds are designed to selectively target and inhibit the activity of thymidine kinase 2 (TK2), an essential enzyme involved in nucleotide metabolism within the cell. TK2 plays a crucial role in the phosphorylation of thymidine, a pyrimidine nucleoside, to form thymidine monophosphate, which is a critical precursor for DNA synthesis. By interfering with the enzymatic activity of TK2, inhibitors of this class disrupt the normal progression of this biochemical pathway.
Through their distinctive chemical structure, these inhibitors are engineered to bind to the active site of TK2, thereby impeding its catalytic function and causing downstream effects on cellular processes dependent on nucleotide production. The development of TK2 inhibitors represents a significant advancement in understanding cellular biochemistry and could offer new avenues for modulating cellular functions through precise enzymatic regulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Masitinib | 790299-79-5 | sc-211777 | 10 mg | $180.00 | ||
Masitinib inhibits TK2 by binding to its ATP-binding pocket, preventing ATP from binding and disrupting the kinase's catalytic activity. This leads to the inhibition of phosphorylation events that are crucial for cellular processes such as DNA replication and repair. | ||||||
AZD1208 | 1204144-28-4 | sc-503188 | 10 mg | $316.00 | 1 | |
AZD1208 inhibits TK2 activity by binding to the kinase's active site, thereby blocking the transfer of phosphate groups. This disruption hinders downstream signaling pathways that rely on phosphorylation events, impacting cellular processes regulated by TK2. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a natural compound, inhibits TK2 by competing with ATP for binding to the kinase's active site. This competition prevents the transfer of phosphate groups, influencing downstream signaling pathways that are dependent on TK2-mediated phosphorylation. | ||||||
WH-4-023 | 837422-57-8 | sc-507457 | 10 mg | $172.00 | ||
WH-4-023 is a TK2 inhibitor that targets the ATP-binding pocket of the kinase domain. By binding to this site, it obstructs the kinase's ability to phosphorylate substrate molecules, leading to alterations in cellular processes driven by tyrosine kinase signaling. | ||||||
BMS 777607 | 1025720-94-8 | sc-364438 sc-364438A | 10 mg 50 mg | $392.00 $1244.00 | 1 | |
BMS-777607 functions as a TK2 inhibitor by binding to the kinase's ATP-binding pocket. This binding event disrupts the kinase's phosphorylation activity, influencing downstream signaling cascades associated with cellular processes modulated by tyrosine kinases. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib inhibits TK2 by binding to the ATP-binding pocket of the kinase domain. This interaction blocks the kinase's ability to transfer phosphate groups, thereby altering the downstream signaling pathways driven by TK2 and affecting various cellular processes. | ||||||
KX2-391 | 897016-82-9 | sc-364520 sc-364520A | 5 mg 50 mg | $180.00 $1140.00 | ||
KX2-391 exerts its TK2 inhibitory effects by binding to the ATP-binding pocket of the kinase domain. This binding interferes with the kinase's ability to phosphorylate substrates, leading to changes in cellular processes governed by tyrosine kinase signaling. | ||||||