Molecular structure of BMS 777607, CAS Number: 1025720-94-8
BMS 777607 (CAS 1025720-94-8)
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Application:
BMS 777607 is a small-molecule inhibitor of Met, Axl, Ron and Tyro3
CAS Number:
1025720-94-8
Molecular Weight:
512.89
Molecular Formula:
C25H19ClF2N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BMS 777607 is a compound that has interest in the field of signal transduction research. It is known to act as an inhibitor of the MET tyrosine kinase receptor, which plays a role in various cellular processes such as growth, regeneration, and survival. In cellular biology, BMS 777607 is utilized to study the downstream effects of MET inhibition, which includes alterations in cell scattering, proliferation, and survival signaling pathways. Additionally, this compound is employed in cancer research to investigate the role of the MET receptor in tumor growth and metastasis. The compound′s effects on cell motility and invasion are further explored in the context of cell migration and tissue repair mechanisms.
BMS 777607 (CAS 1025720-94-8) References
- Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily. | Schroeder, GM., et al. 2009. J Med Chem. 52: 1251-4. PMID: 19260711
- Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation. | Dai, Y., et al. 2012. Clin Exp Metastasis. 29: 253-61. PMID: 22286523
- Constitutively active c-Met kinase in PC-3 cells is autocrine-independent and can be blocked by the Met kinase inhibitor BMS-777607. | Dai, Y. and Siemann, DW. 2012. BMC Cancer. 12: 198. PMID: 22639908
- Small-molecule inhibitor BMS-777607 induces breast cancer cell polyploidy with increased resistance to cytotoxic chemotherapy agents. | Sharma, S., et al. 2013. Mol Cancer Ther. 12: 725-36. PMID: 23468529
- Synergistic activities of MET/RON inhibitor BMS-777607 and mTOR inhibitor AZD8055 to polyploid cells derived from pancreatic cancer and cancer stem cells. | Zeng, JY., et al. 2014. Mol Cancer Ther. 13: 37-48. PMID: 24233399
- Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics. | Sharma, S., et al. 2014. Mol Oncol. 8: 469-82. PMID: 24444656
- Discovery of novel type II c-Met inhibitors based on BMS-777607. | Zhang, W., et al. 2014. Eur J Med Chem. 80: 254-66. PMID: 24792774
- BMS-777607 promotes megakaryocytic differentiation and induces polyploidization in the CHRF-288-11 cells. | Nurhayati, RW., et al. 2015. Hum Cell. 28: 65-72. PMID: 25304900
- Inhibiting receptor tyrosine kinase AXL with small molecule inhibitor BMS-777607 reduces glioblastoma growth, migration, and invasion in vitro and in vivo. | Onken, J., et al. 2016. Oncotarget. 7: 9876-89. PMID: 26848524
- Antitumor effects of BMS-777607 on ovarian cancer cells with constitutively activated c-MET. | Wu, CC., et al. 2019. Taiwan J Obstet Gynecol. 58: 145-152. PMID: 30638469
- When RON MET TAM in Mesothelioma: All Druggable for One, and One Drug for All? | Baird, AM., et al. 2019. Front Endocrinol (Lausanne). 10: 89. PMID: 30863365
- Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer. | Kasikara, C., et al. 2019. Cancer Res. 79: 2669-2683. PMID: 30877108
- A C-Met chemical inhibitor promotes fracture healing through interacting with osteogenic differentiation via the mTORC1 pathway. | Wang, R., et al. 2019. Exp Cell Res. 381: 50-56. PMID: 31034806
- [Effect of Met kinase inhibitor BMS-777607 on proliferation and apoptosis of tongue cell line CAL 27 squamous cell carcinoma]. | Ma, ZL., et al. 2021. Shanghai Kou Qiang Yi Xue. 30: 573-578. PMID: 35587009
Inhibitor of:
Axl, Gas6, HGF, HOP-1, KIAA1751, MerTK, Met, Olfr547, Ron, TK2, and Tyro3.Activator of:
GRB7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMS 777607, 10 mg | sc-364438 | 10 mg | $400.00 | |||
BMS 777607, 50 mg | sc-364438A | 50 mg | $1269.00 |