Molecular structure of AZD1208, CAS Number: 1204144-28-4
AZD1208 (CAS 1204144-28-4)
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Alternate Names:
(5Z)-5-[[2-[(3R)-3-Amino-1-piperidinyl][1,1′-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione
CAS Number:
1204144-28-4
Molecular Weight:
379.48
Molecular Formula:
C21H21N3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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AZD1208, an orally available small molecule inhibitor, holds promise as an antineoplastic agent by targeting PIM kinases. This pan-PIM kinase inhibitor suppresses the activities of PIM1, PIM2, and PIM3 serine/threonine kinases. Consequently, it disrupts the G1/S phase cell cycle transition, leading to cell cycle arrest and triggering apoptosis in cells that exhibit elevated PIM expression. The growth inhibition observed in multiple leukemia cell lines upon treatment with AZD1208 is correlated with the levels of PIM1, a substrate of STAT transcription factors. Notably, PIM kinases serve as downstream effectors in various cytokine and growth factor signaling pathways and exhibit upregulation in different malignancies.
AZD1208 (CAS 1204144-28-4) References
- AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. | Keeton, EK., et al. 2014. Blood. 123: 905-13. PMID: 24363397
- PIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancer. | Kirschner, AN., et al. 2015. J Natl Cancer Inst. 107: PMID: 25505253
- The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells. | Mazzacurati, L., et al. 2015. Oncotarget. 6: 40141-57. PMID: 26472029
- The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. | Harada, M., et al. 2015. Oncotarget. 6: 37930-47. PMID: 26473447
- Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas. | Kreuz, S., et al. 2015. Mol Cancer. 14: 205. PMID: 26643319
- Protein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemia. | Chen, LS., et al. 2016. Leuk Lymphoma. 57: 2863-2873. PMID: 27054578
- AZD1208, a pan-Pim kinase inhibitor, inhibits adipogenesis and induces lipolysis in 3T3-L1 adipocytes. | Park, YK., et al. 2018. J Cell Mol Med. 22: 2488-2497. PMID: 29441719
- Pan-Pim Kinase Inhibitor AZD1208 Suppresses Tumor Growth and Synergistically Interacts with Akt Inhibition in Gastric Cancer Cells. | Lee, M., et al. 2019. Cancer Res Treat. 51: 451-463. PMID: 29879757
- AZD1208, a Pan-Pim Kinase Inhibitor, Has Anti-Growth Effect on 93T449 Human Liposarcoma Cells via Control of the Expression and Phosphorylation of Pim-3, mTOR, 4EBP-1, S6, STAT-3 and AMPK. | Yadav, AK., et al. 2019. Int J Mol Sci. 20: PMID: 30654529
- New Mechanistic Insight on the PIM-1 Kinase Inhibitor AZD1208 Using Multidrug Resistant Human Erythroleukemia Cell Lines and Molecular Docking Simulations. | Marques, MB., et al. 2019. Curr Top Med Chem. 19: 914-926. PMID: 31072293
- PIM kinase inhibitor, AZD1208, inhibits protein translation and induces autophagy in primary chronic lymphocytic leukemia cells. | Cervantes-Gomez, F., et al. 2019. Oncotarget. 10: 2793-2809. PMID: 31073371
- Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma. | Silva, A., et al. 2021. Blood. 138: 1040-1052. PMID: 33970999
- Toxic effects of AZD1208 on mouse oocytes and its possible mechanisms. | Yan, FZ., et al. 2022. J Cell Physiol. 237: 3661-3670. PMID: 35853150
Inhibitor of:
BRAP, Dppa1, FEM-3, HUNK, IL-15, ISG20L1, Pim-1, Pim-3, Rhox9, RIA1, Sam 68, TEF-1, and TK2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AZD1208, 10 mg | sc-503188 | 10 mg | $322.00 |