Timeless Inhibitors
TIMELESS inhibitors, compounds that would be categorized as such would be those that can modulate the function of the TIMELESS protein. Since TIMELESS is involved in the circadian rhythm, DNA damage response, and replication, inhibitors might target these processes to modulate the activity of TIMELESS indirectly.
Compounds such as caffeine or lithium chloride may disrupt the circadian regulation, while kinase inhibitors like KU-55933 or NU7441 could alter the DNA damage response, affecting TIMELESS activity in the process. Similarly, inhibitors of DNA replication enzymes or cell cycle regulators, such as aphidicolin and roscovitine, may have indirect effects on TIMELESS by influencing the cellular processes it is involved in. However, the specificity and direct impact of these compounds on TIMELESS are not well-established, and their influence would arise from the broader impact on cellular pathways rather than direct inhibition of the TIMELESS protein itself.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine can influence circadian rhythms and potentially disrupt TIMELESS-related pathways by antagonizing adenosine receptors. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR signaling, which can affect circadian rhythm and DNA damage response, processes in which TIMELESS is implicated. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
As an ATM kinase inhibitor, KU-55933 may indirectly affect TIMELESS function by altering the DNA damage response. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
NU7441 is a DNA-PK inhibitor, which could potentially affect the DNA damage repair pathway and indirectly the function of TIMELESS. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE-821 is an ATR inhibitor; given TIMELESS's role in DNA replication, inhibiting ATR may have downstream effects on TIMELESS activity. | ||||||
UCN-01 | 112953-11-4 | sc-202376 | 500 µg | $246.00 | 10 | |
UCN-01 inhibits CHK1, which is involved in cell cycle control and DNA damage response, possibly affecting TIMELESS indirectly. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Inhibits cyclin-dependent kinases (CDKs) and could potentially impact the cell cycle and replication processes involving TIMELESS. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
A DNA polymerase inhibitor that could indirectly affect TIMELESS by disrupting DNA replication processes. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that could impact gene expression patterns, potentially influencing TIMELESS expression or function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Used to affect circadian rhythms, it may indirectly influence TIMELESS by modulating glycogen synthase kinase 3 (GSK-3) activity. | ||||||