THSD4 Inhibitors

THSD4 inhibitors represent a diverse group of chemicals targeting key cellular processes involved in cell adhesion, migration, and survival. Y-27632 and H-1152, as ROCK inhibitors, modulate cytoskeletal dynamics by altering actin organization, impacting THSD4-associated processes related to cell adhesion and migration. NSC23766, a Rac1-specific inhibitor, influences small GTPase signaling, impacting cellular protrusions and cytoskeletal dynamics, thus affecting THSD4-associated processes related to cell migration and invasion. Latrunculin A, an actin polymerization inhibitor, disrupts cytoskeletal dynamics, altering cellular protrusions and influencing THSD4-associated processes related to cell migration and adhesion. LY294002, SB431542, and ML141 target PI3K, TGF-β receptor, and Cdc42, respectively, influencing downstream signaling events and impacting THSD4-associated processes related to cell survival, adhesion, and migration.

Blebbistatin, a myosin II inhibitor, modulates actomyosin contractility, altering cytoskeletal dynamics and cellular contractility, impacting THSD4-associated processes related to cell migration and adhesion. PP2, a Src family kinase inhibitor, modulates tyrosine kinase signaling, affecting downstream events and impacting THSD4-associated processes related to cell adhesion and migration. Cytosporone B, a nuclear receptor antagonist, modulates transcriptional regulation, altering gene expression patterns and influencing THSD4-associated processes related to cell survival and migration. SB203580, a p38 MAPK inhibitor, modulates signaling cascades, impacting THSD4-associated processes related to cell adhesion and migration. Rapamycin, an mTOR inhibitor, influences mTOR-mediated pathways, affecting downstream events and impacting THSD4-associated processes related to cell survival and migration. This diverse set of inhibitors provides valuable tools for investigating the intricate regulatory networks involving THSD4, offering insights into its role in cellular processes critical for cancer progression and other pathological conditions.