THAP4 Inhibitors
THAP4 is a member of the THAP (Thanatos-associated protein) family, known for distinct cellular roles and interactions within various pathways. Within the realm of molecular biology and cellular signaling, understanding the modulation of such proteins is paramount. THAP4 inhibitors affect THAP4's activity or the cellular pathways closely related to it. Rapamycin, for instance, by inhibiting the mTORC1 complex, showcases an indirect avenue through which protein synthesis might be altered, subsequently affecting the operations of THAP4. Staurosporine, with its broad kinase inhibitory activities, offers an insight into how the global protein phosphorylation landscape can be tweaked, and thus the milieu in which THAP4 functions.
Other members of this class further exemplify the strategic modulation of THAP4 or its associated pathways. Wortmannin and LY294002, which target PI3K, signify the intent to modulate diverse cellular processes that might intersect with THAP4's functional realm. The ERK and JNK pathways, critical conduits of intracellular signaling, when influenced by compounds like PD98059, U0126, or SP600125, highlight the alteration of transcriptional activities or other signaling events wherein THAP4 could play a role. Compounds like Brefeldin A or Cycloheximide add another layer of complexity by influencing protein transport and synthesis, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTORC1 complex, potentially influencing protein synthesis and processes where THAP4 is involved. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Broad-spectrum protein kinase inhibitor; by altering phosphorylation, can influence pathways where THAP4 operates. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Inhibits protein phosphatases, potentially affecting phosphorylation events related to THAP4. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Targets PI3K, thus can impact pathways that intersect with THAP4's function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Interferes with protein transport, which can influence THAP4's proper localization or function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, potentially impacting cellular processes tied to THAP4. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Targets JNK, can influence transcriptional activities associated with THAP4. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Influences the ERK pathway, potentially affecting THAP4's functional roles. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Affects protein phosphatase activity, potentially altering THAP4's function or interactions. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Disrupts protein synthesis, potentially affecting the levels or interactions of THAP4. | ||||||