Date published: 2026-3-17

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TFII-I Inhibitors

TFII-I inhibitors belong to a specific chemical class that targets the transcription factor II-I (TFII-I) proteins. Transcription factors are essential regulatory proteins that modulate gene expression by controlling the transcription of specific genes. TFII-I, in particular, plays a significant role in this process, as it regulates the activity of various genes involved in critical cellular functions. TFII-I is known to be involved in the control of cell proliferation, differentiation, and apoptosis, making it a promising target for research in various fields. TFII-I inhibitors are chemical compounds designed to selectively bind to TFII-I proteins, thereby disrupting their normal function. By inhibiting the activity of TFII-I, these compounds can potentially influence gene expression patterns and impact cellular processes in a controlled manner. This selective interference with TFII-I's regulatory role can lead to a better understanding of the intricate molecular mechanisms that govern cellular functions.

Due to their specialized nature, TFII-I inhibitors are subject to rigorous testing and evaluation in the scientific community. Researchers are particularly interested in exploring the potential of these inhibitors in gaining insights into various biological processes, including cell development, tissue repair, and disease progression. Understanding the impact of TFII-I inhibition may pave the way for novel discoveries in cell biology and open up new avenues for targeted molecular interventions. As research in the field progresses, scientists are continuously optimizing TFII-I inhibitors to enhance their specificity and efficacy. By further elucidating the interactions between these inhibitors and TFII-I proteins, researchers aim to expand our knowledge of gene regulation, transcriptional control, and their relevance in health and disease. Overall, TFII-I inhibitors represent a fascinating class of chemical compounds with great potential to deepen our understanding of cellular processes and may eventually offer new perspectives on biomedical research.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Ciclopirox

29342-05-0sc-217893
25 mg
$207.00
2
(1)

Ciclopirox is an antifungal and anti-inflammatory agent that has been shown to inhibit TFII-I activity. It is used primarily for fungal infections but has also demonstrated potential as a TFII-I inhibitor.

CX-4945

1009820-21-6sc-364475
sc-364475A
2 mg
50 mg
$183.00
$800.00
9
(2)

CX-4945 is a potent and selective inhibitor of protein kinase CK2, which has been found to downregulate TFII-I activity.

6-Thioguanine

154-42-7sc-205587
sc-205587A
250 mg
500 mg
$42.00
$54.00
3
(1)

6-thioguanine is an immunosuppressive drug that has been found to inhibit TFII-I activity.

Benzyl isothiocyanate

622-78-6sc-204641
sc-204641A
5 g
25 g
$47.00
$156.00
1
(0)

This natural compound found in cruciferous vegetables, such as broccoli and cabbage, has been identified as a TFII-I inhibitor.

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$90.00
$204.00
13
(1)

Triptolide is a diterpene triepoxide found in the Chinese medicinal herb Tripterygium wilfordii.

Thioridazine

50-52-2sc-473180
50 mg
$500.00
(0)

Thioridazine is an antipsychotic drug that has been shown to inhibit TFII-I activity.

JIB 04

199596-05-9sc-397040
20 mg
$177.00
(0)

JIB-04 is a small-molecule inhibitor that targets the lysine-specific demethylase 4 (LSD1). By inhibiting LSD1, JIB-04 indirectly affects TFII-I function and has been investigated for its anti-cancer effects.

Emetine

483-18-1sc-470668
sc-470668A
sc-470668B
sc-470668C
1 mg
10 mg
50 mg
100 mg
$440.00
$900.00
$1400.00
$2502.00
(0)

Emetine is an alkaloid found in the ipecac root and has been identified as a TFII-I inhibitor.

Andrographolide

5508-58-7sc-205594
sc-205594A
50 mg
100 mg
$15.00
$40.00
7
(1)

Andrographolide is a bioactive compound found in Andrographis paniculata, a medicinal plant. It has been reported to inhibit TFII-I activity and has potential anti-inflammatory and anti-cancer effects.