Testin-2 Inhibitors
Testin-2 inhibitors are a class of chemical compounds characterized by their ability to interact with and inhibit the activity of an enzyme referred to as Testin-2. The chemical structures of Testin-2 inhibitors are diverse, yet they share a common functional attribute – the capacity to bind to the active site of Testin-2 or modulate its activity through allosteric interactions. These interactions can lead to a conformational change in the enzyme, which in turn affects its ability to catalyze its specific biochemical reactions. The design and development of these inhibitors often involve a meticulous process of chemical synthesis and structure-activity relationship (SAR) studies, which help in identifying the functional groups necessary for high-affinity binding and inhibition.
Within the molecular framework of Testin-2 inhibitors, one might find a variety of chemical moieties, such as heterocycles, aromatic rings, and aliphatic chains, which are crucial for the specificity and potency of the inhibitors. The binding affinity of these compounds is a result of non-covalent interactions such as hydrogen bonding, hydrophobic forces, van der Waals interactions, and sometimes even covalent bonds. Inhibitors may be designed to mimic the natural substrate of Testin-2, thereby competing with the substrate for binding to the enzyme. Alternatively, they may be structured to bind to distinct sites on the enzyme, which can induce indirect effects on the active site. The precise inhibition mechanism can be complex, often requiring comprehensive analysis through biochemical assays, X-ray crystallography, or NMR spectroscopy to elucidate. These investigative approaches allow chemists and biochemists to understand the three-dimensional interaction between the inhibitor and Testin-2, guiding further refinement of the inhibitor compounds for increased specificity and potency.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent and specific inhibitor of phosphoinositide 3-kinases (PI3Ks). By inhibiting PI3Ks, LY294002 prevents the phosphorylation and activation of Akt, a downstream effector in the PI3K pathway. As Testin-2 has been suggested to be involved in cell survival and proliferation via the PI3K/Akt pathway, inhibition of this pathway by LY294002 can lead to a decrease in Testin-2-mediated cellular functions. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another potent inhibitor of PI3K. Similar to LY294002, Wortmannin's inhibition of PI3K activity leads to a reduction in Akt phosphorylation, which can disrupt Testin-2's role in cell survival signaling pathways. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which functions upstream of extracellular signal-regulated kinases (ERK1/2) in the MAPK pathway. Testin-2, which may be involved in cell migration and adhesion processes that are regulated by the MAPK pathway, could have its function impaired due to the inhibition of MEK and subsequent decrease in ERK1/2 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. By impeding the p38 MAPK pathway, SB203580 could interfere with Testin-2-regulated stress response and inflammatory processes, ultimately leading to diminished Testin-2 activity in these pathways. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. Src kinases are involved in multiple signaling cascades, and their inhibition by PP2 could affect cellular processes such as adhesion and migration in which Testin-2 is implicated. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor with activity against Src family kinases. By inhibiting these kinases, Dasatinib could disrupt the cytoskeletal dynamics and cell adhesion processes in which Testin-2 is potentially involved, leading to decreased Testin-2 function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of the Rho-associated protein kinase (ROCK). Since Testin-2 has been linked to actin cytoskeleton organization and may interact with proteins in the Rho signaling pathway, inhibition of ROCK by Y-27632 could impair Testin-2's role in these processes. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an immunosuppressant that inhibits calcineurin. As Testin-2 might be involved in T-cell activation where calcineurin plays a crucial role, Cyclosporin A may indirectly decrease Testin-2's functional activity in immune response modulation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, leading to a blockade of the ERK1/2 MAPK pathway. This can hinder the signaling events that regulate cell proliferation and differentiation, potentially affecting the processes that Testin-2 is involved in. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of the c-Jun N-terminal kinase (JNK), which is part of the MAPK signaling pathways. By inhibiting JNK, SP600125 may affect Testin-2's role in apoptosis and cell differentiation. | ||||||