TAL2 Activators
TAL2 is a transcription factor that plays a crucial role in the regulation of gene expression involved in cell differentiation, development, and proliferation. As a member of the basic helix-loop-helix (bHLH) family of transcription factors, TAL2 influences the expression of genes critical for hematopoietic development and has been implicated in T-cell lineage commitment. The functional activation of TAL2 is integral to its role in cellular processes, and understanding the mechanisms of its activation can provide insights into its involvement in normal physiological functions and diseases.
Activation of TAL2 involves complex signaling pathways that modulate its activity and expression. Indirect activators of TAL2 may influence its activity by affecting cellular signaling pathways that regulate transcription factor activity, protein-protein interactions, and post-translational modifications. These activators operate through various mechanisms, including modulation of cAMP levels, activation of protein kinases, and inhibition of phosphodiesterases or histone deacetylases. By influencing these pathways, chemicals such as Forskolin, IBMX, and PMA can indirectly promote the functional activation of TAL2, enhancing its role in gene expression regulation and cellular differentiation. The interplay between these signaling molecules and pathways underscores the complexity of TAL2 activation and highlights the importance of a multifaceted approach to understanding its regulation and function in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates cAMP levels, which in turn activates protein kinase A (PKA). PKA then phosphorylates target proteins, leading to the activation of TAL2 by enhancing its regulatory functions in the cell. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX prevents the breakdown of cAMP, maintaining elevated levels of this secondary messenger. The sustained activation of PKA facilitates the activation of TAL2 through enhanced cellular signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which modifies signaling pathways by phosphorylating various proteins. These changes in cellular signaling indirectly lead to the activation of TAL2, integrating it more effectively into cell regulation processes. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR stimulates AMP-activated protein kinase (AMPK), a regulator of energy homeostasis, which then affects multiple signaling pathways. This activation can indirectly lead to TAL2 activation by altering the cell’s metabolic and energy-related processes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid interacts with retinoic acid receptors (RARs) to modulate gene expression related to cell differentiation and development. This modulation can lead to the activation of TAL2 by affecting the transcriptional networks and cellular pathways it is involved in. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases (HDACs), leading to changes in chromatin structure that facilitate gene expression. The inhibition of HDACs indirectly promotes TAL2 activation by enhancing the transcription of genes within pathways TAL2 influences. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine promotes autophagy, a process that can affect cellular signaling pathways and homeostasis. Through these changes, spermidine indirectly supports TAL2 activation, aligning with its role in cellular growth and response to stress. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), leading to an increase in intracellular cAMP levels and subsequent PKA activation. This process enhances the signaling pathways that contribute to TAL2 activation, promoting its regulatory role in the cell. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin influences NF-kB and other signaling pathways involved in inflammation and oxidative stress. By modulating these pathways, curcumin indirectly supports TAL2 activation, promoting cellular protection and homeostasis. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate, as an HDAC inhibitor, facilitates a more open chromatin structure, enhancing gene expression. This action indirectly promotes TAL2 activation by enabling the transcription of genes in pathways where TAL2 plays a crucial role. | ||||||