TAB1 Activators
The chemical class of TAB1 activators consists of compounds that intricately modulate cellular pathways, ultimately influencing the activation of TAB1. Anisomycin, a JNK activator, directly engages the JNK signaling pathway, leading to the phosphorylation and activation of TAB1 within the TAK1 complex. This activation is pivotal in orchestrating various cellular responses, particularly those associated with inflammation and stress. TAK-1 Inhibitor (5Z)-7-Oxozeaenol serves as an indirect regulator, disrupting the TAK1-TAB1 interaction and impacting downstream signaling pathways. It exemplifies the intricate balance between activators and inhibitors in fine-tuning cellular responses. PMA (Phorbol 12-myristate 13-acetate), by activating PKC, indirectly influences TAB1 activation and contributes to cellular processes mediated by TAB1-dependent signaling cascades.
LPS (Lipopolysaccharide), a component of Gram-negative bacteria, directly activates the TAK1 complex, initiating the phosphorylation and activation of TAB1. This activation is associated with the coordination of inflammatory responses, showcasing the role of TAB1 in immune regulation. Sorbitol, through the activation of the ASK1-MAPK kinase pathway, serves as an indirect activator of TAB1, impacting cellular processes responsive to osmotic stress. CDDO (2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid) indirectly influences TAB1 by activating the Keap1-Nrf2 pathway, providing insights into the interconnectedness of cellular defense mechanisms. Phorbol 12,13-dibutyrate, by activating PKC, indirectly activates TAB1 and participates in immune and inflammatory responses. Angiotensin II, a regulator of cardiovascular function, indirectly activates TAB1 through the TAK1-MKK3/6-p38 pathway. Phosphatidic Acid serves as an indirect activator of TAB1 by modulating the TAK1-MKK3/6-p38 pathway, impacting cellular stress responses. Thrombin, a serine protease, directly activates TAB1, linking its role to blood clotting, inflammation, and cell proliferation. This diverse array of TAB1 activators highlights the intricate regulatory mechanisms governing cellular responses, providing a foundation for understanding the broader cellular context in which TAB1 operates.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin, a potent JNK activator, directly influences the JNK signaling pathway. This activation leads to the phosphorylation and subsequent activation of TAB1, which acts as an adaptor protein in the TAK1 complex, ultimately promoting its role in various cellular responses, including inflammation and stress responses. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates PKC, which in turn can phosphorylate and activate the TAK1 complex. This leads to the activation of TAB1 within the complex, influencing downstream signaling events. The activation of PKC by PMA can thus serve as an indirect activator of TAB1, impacting cellular processes mediated by TAB1-dependent signaling pathways. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS, a component of the outer membrane of Gram-negative bacteria, activates the TAK1 complex. The activated TAK1 complex, in turn, phosphorylates TAB1, leading to its activation. This direct activation of TAB1 by LPS is associated with the regulation of inflammatory responses and immune signaling cascades, highlighting the role of TAB1 in coordinating cellular responses to bacterial infections. | ||||||
D-Sorbitol | 50-70-4 | sc-203278A sc-203278 | 100 g 1 kg | $29.00 $69.00 | ||
Sorbitol activates the ASK1-MAPK kinase pathway, leading to the phosphorylation and activation of the TAK1 complex. This activation subsequently impacts TAB1, which functions within the TAK1 complex. Sorbitol, by modulating this pathway, serves as an indirect activator of TAB1, influencing cellular processes regulated by TAB1-dependent signaling, including responses to osmotic stress and cellular homeostasis. | ||||||
Phorbol-12,13-dibutyrate | 37558-16-0 | sc-202285 | 1 mg | $124.00 | 3 | |
Phorbol 12,13-dibutyrate, an activator of PKC, induces the phosphorylation and activation of the TAK1 complex. This activation leads to the phosphorylation of TAB1, influencing its role in downstream signaling pathways. By activating PKC, this chemical indirectly serves as an activator of TAB1, impacting cellular processes regulated by TAB1-dependent signaling cascades, including immune responses and inflammation. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II activates the TAK1-MKK3/6-p38 pathway, resulting in the phosphorylation and activation of the TAK1 complex. This activation subsequently impacts TAB1, which functions within the TAK1 complex. Angiotensin II, by modulating this pathway, serves as an indirect activator of TAB1, influencing cellular processes regulated by TAB1-dependent signaling, including those associated with cardiovascular function and inflammation. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Thrombin activates the TAK1 complex, leading to the phosphorylation and activation of TAB1. This direct activation of TAB1 is integral to the initiation of downstream signaling pathways associated with thrombin responses, including those involved in blood clotting, inflammation, and cell proliferation. The modulation of TAB1 by thrombin highlights its crucial role in mediating cellular responses to this serine protease. | ||||||