Syntaxin 1B Activators
Phorbol 12-myristate 13-acetate, diacylglycerol, and arachidonic acid activate protein kinase C (PKC). PKC phosphorylates Munc18, a protein known to bind and regulate Syntaxin 1B, leading to enhanced Syntaxin 1B activity. Forskolin and 8-Bromo-cAMP elevate cAMP levels, activating protein kinase A (PKA). PKA phosphorylates SNAP-25, a SNARE protein that interacts with Syntaxin 1B, enhancing Syntaxin 1B activity.
Okadaic Acid inhibits protein phosphatases 1 and 2A, leading to enhanced phosphorylation of Syntaxin 1B-interacting proteins and enhancing Syntaxin 1B activity. Calmodulin binds to and activates Syntaxin 1B, meaning an increase in calmodulin can enhance the functional activity of Syntaxin 1B. Calcium chloride provides calcium ions essential for SNARE-complex formation, hence increasing calcium concentrations can enhance the functional activity of Syntaxin 1B by promoting SNARE-complex formation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC). PKC can phosphorylate Munc18, a protein known to bind and regulate Syntaxin 1B, potentially leading to enhanced Syntaxin 1B activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cAMP levels. Elevated cAMP can activate protein kinase A (PKA), which can phosphorylate SNAP-25, a SNARE protein that interacts with Syntaxin 1B, potentially enhancing Syntaxin 1B activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a membrane-permeable cAMP analog. Elevated cAMP can activate protein kinase A (PKA), which can phosphorylate SNAP-25, potentially enhancing Syntaxin 1B activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A. Inhibition of these phosphatases can lead to enhanced phosphorylation of Syntaxin 1B-interacting proteins, potentially enhancing Syntaxin 1B activity. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $300.00 | ||
Calmodulin binds to Syntaxin 1B, leading to Syntaxin 1B activation. An increase in calmodulin can enhance the functional activity of Syntaxin 1B by promoting its own activation. | ||||||
R 59-022 | 93076-89-2 | sc-203227 | 5 mg | $124.00 | 1 | |
Diacylglycerol activates protein kinase C (PKC). PKC can phosphorylate Munc18, a protein known to bind and regulate Syntaxin 1B, potentially leading to enhanced Syntaxin 1B activity. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium ions are essential for SNARE-complex formation. Increasing calcium concentrations can enhance the functional activity of Syntaxin 1B by promoting SNARE-complex formation. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic Acid can be converted to diacylglycerol, which activates protein kinase C (PKC). PKC can phosphorylate Munc18, a protein known to bind and regulate Syntaxin 1B, potentially leading to enhanced Syntaxin 1B activity. | ||||||