Syntaphilin Inhibitors

Syntaphilin inhibitors represent a chemical class of compounds that primarily target a specific protein known as syntaphilin. Syntaphilin, also referred to as SNAPIN or Synaptotagmin-associated protein, is a crucial regulator of mitochondrial transport within neurons. Mitochondria are organelles responsible for generating energy in the form of adenosine triphosphate (ATP), and their proper distribution within neurons is vital for the maintenance of neuronal health and function. Syntaphilin normally acts as a tethering protein, anchoring mitochondria to microtubules and hindering their mobility within axons. This tethering process helps to regulate mitochondrial distribution and maintain energy balance in neurons.Syntaphilin inhibitors are designed to disrupt this interaction between syntaphilin and microtubules, thereby promoting the movement of mitochondria along axons. By inhibiting syntaphilin, these compounds facilitate the dynamic transport of mitochondria to regions of high energy demand within neurons, such as synapses.