Date published: 2025-12-29

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Syk Inhibitors

Syk inhibitors, short for Spleen Tyrosine Kinase inhibitors, belong to a class of small molecules that have garnered significant attention in the field of molecular biology and drug development. These compounds primarily target the Spleen Tyrosine Kinase, a cytoplasmic protein kinase that plays a crucial role in signal transduction within immune cells, particularly B cells and mast cells. The inhibition of Syk is pivotal in modulating various cellular processes, making Syk inhibitors a prominent area of research in understanding cell signaling mechanisms.Syk itself is a non-receptor tyrosine kinase that is activated upon binding of antigen receptors such as the B-cell receptor (BCR) and the high-affinity IgE receptor (FcεRI). Upon activation, Syk initiates a cascade of phosphorylation events that ultimately lead to the activation of downstream signaling pathways. Syk inhibitors act by binding to the kinase's active site, preventing its phosphorylation and thereby inhibiting its downstream signaling effects. This mechanism of action has made Syk inhibitors valuable tools in studying immune cell function and signaling pathways.

Items 11 to 14 of 14 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MNS

1485-00-3sc-202229
50 mg
$87.00
1
(0)

MNS functions as a Syk inhibitor by engaging with the kinase's active site, leading to a conformational shift that diminishes its catalytic activity. This compound exhibits a high degree of specificity, allowing it to disrupt critical protein-protein interactions essential for Syk-mediated signaling pathways. The unique molecular interactions of MNS result in altered reaction kinetics, effectively slowing down the phosphorylation cascade and influencing cellular responses. Its structural properties enhance binding stability, further inhibiting Syk's role in signal propagation.

(2-Oxo-morpholin-4-yl)-acetic acid

302900-65-8sc-308547
500 mg
$250.00
(0)

(2-Oxo-morpholin-4-yl)-acetic acid acts as a Syk inhibitor by selectively binding to the enzyme's regulatory domain, inducing a structural rearrangement that impairs its function. This compound demonstrates unique interaction dynamics, modulating the affinity for substrate molecules and altering downstream signaling events. Its distinct molecular architecture promotes enhanced solubility and bioavailability, facilitating effective disruption of Syk-related pathways and influencing cellular behavior.

BAY 61-3606

sc-507485
2 mg
$345.00
1
(0)

BAY 61-3606 is a reversible SYK inhibitor that interferes with B-cell receptor signaling and can be explored for B-cell-related disorders.

GS 9973

1229208-44-9sc-490337
sc-490337A
sc-490337B
sc-490337C
sc-490337D
10 mg
50 mg
100 mg
500 mg
1 g
$250.00
$878.00
$1353.00
$5500.00
$9000.00
(0)

Entospletinib targets SYK and inhibits downstream signaling in B-cells, reducing their proliferation and survival.