MNS CAS: 1485-00-3
MF: C9H7NO4
MW: 193.16
A selective inhibitor of Syk kinase activity.

MNS (CAS 1485-00-3)

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Alternate Names: Syk Inhibitor III
Application: MNS is a selective inhibitor of Syk kinase activity
CAS Number: 1485-00-3
Purity: ≥99%
Molecular Weight: 193.16
Molecular Formula: C9H7NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

MNS is a selective inhibitor of c-Src and Syk tyrosine kinases also known as 3,4-methylenedioxy-β-nitrostyrene. MNS acts as a cell-permeable cytotoxic β-nitrostyrene derivative which suppresses human platelet aggregation. In addition, platelets previously aggregated by ADP, U46619, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu can be disaggregated by MNS. Studies suggest the mechanism responsible for this inhibition is observed via prevention of glycoprotein IIb/IIIa activation.


References

1. Wang, W.Y., et al. 2006. Mol. Pharmacol. 70: 1380-1389. PMID: 16837624
2. Hsieh, P.W., et al. 2010. Bioorg. Med. Chem. 18: 7621-7627. PMID: 20850977

Physical State :
Solid
Solubility :
DMSO
Storage :
Store at -20° C
Melting Point :
159-163° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
WL5270000
PubChem CID :
672296
SMILES :
C1OC2=C(O1)C=C(C=C2)C=C[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

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MNS (CAS 1485-00-3)  Product Citations

See how others have used MNS (CAS 1485-00-3). Click on the entry to view the PubMed entry .

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PMID: # 26690982  Kondo, K. et al. 2015. PLoS ONE. 10: e0144803.

Citations 1 to 1 of 1 total
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